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| Name | Class |
|---|---|
| Korean Cancer Study Group | OTHER |
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Based on targeted NGS panel results, metastatic gastric cancer patients with gene amplifications will receive either anti-EGFR antibody (GC-1118) in combination with weekly paclitaxel as a second-line therapy.
Participants will receive each treatment if the gastric cancer tissue sample reveals either EGFR gene amplification or strong (3+ or 2+) EGFR immunostaining
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| anti-EGFR | Experimental | Participants will receive GC-1118 in combination with weekly paclitaxel. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Anti-EGFR antibody in combination with weekly paclitaxel | Drug | Intravenous GC-1118 in combination with weekly paclitaxel for EGFR-amplified cancer cancers as a second-line therapy |
| Measure | Description | Time Frame |
|---|---|---|
| Response rate | Response rate will be assessed using CT/MRI according to RECIST v1.1. | Response rate will be assessed at 8 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| Progression-free survival | Time from date of enrollment until the date of first documented progression or the date of death from any cause, whichever came first, will be assessed. | From date of enrollment until the date of first documented progression or the date of death from any cause, whichever came first, will be assessed up to 1 year. |
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Key inclusion criteria
Key exclusion criteria
1.Prior exposure to taxane or EGFR-targeted therapy
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hark K Kim, M.D.,Ph.D | Contact | +82-31-920-2238 | hkim@ncc.re.kr |
| Name | Affiliation | Role |
|---|---|---|
| Hark K Kim, M.D.,Ph.D | National Cancer Center, Korea | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Cancer Center | Recruiting | Goyang-si | Gyeonggi-do | 10408 | South Korea |
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| ID | Term |
|---|---|
| C000611922 | GC1118 |
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