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The primary aim of this study is to determine whether a computerized inhibitory control training (ICT) will improve CBT treatment outcomes for Bulimia Nervosa and Binge Eating Disorder.
This study involves a brief phone screen and baseline assessment to determine eligibility. Participants who are eligible for the study will receive 12 sessions of CBT treatment and will be randomly assigned to an ICT or ICT sham condition which will consist of completing ICT computer tasks on a daily basis during the first four weeks of treatment and booster sessions following treatment. Participants will also complete research assessments at mid-treatment, post-treatment, and 3-month follow-up intervals. Research assessments include a battery of questionnaires, computerized tasks, interviews, and behavioral tasks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CBT + ICT | Active Comparator | Participants randomized to the ICT condition will complete a computerized ICT training at home during the first 4 weeks of treatment and ICT "boosters" following their treatment sessions during weeks 5-12. |
|
| CBT + sham | Sham Comparator | Participants randomized to the sham condition will complete a computerized sham ICT training at home during the first 4 weeks of treatment and sham ICT "boosters" following their treatment sessions during weeks 5-12. The shame will contain the same proportion of food as non-food but no inhibitory training component. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CBT | Behavioral | Participants will complete 12 sessions of CBT |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Eating Disorder Examination (EDE) | The Eating Disorder Examination is a widely utilized, semi-structured interview for the assessment of eating disorder symptoms and the binge-eating module will be used to determine binge episode frequency. | Change in binge frequency from baseline to post-treatment and 3-month follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| Food Frequency Questionnaire (FFQ) | A modified version of the Food Frequency Questionnaire will be used to examine changes in binge eating on specific foods in the last month | Change from baseline to post-treatment and 3-month follow up |
| Measure | Description | Time Frame |
|---|---|---|
| Go/No-Go (GNG) | Performance on the Go/No-Go computer task will be used to assess changes in inhibitory control | Change from baseline to post-treatment and 3-month follow up |
| Laboratory Sham Taste Test |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lindsay Gillikin, BA | Contact | 215-553-7110 | EDresearch@drexel.edu |
| Name | Affiliation | Role |
|---|---|---|
| Stephanie Manasse, PhD | Drexel University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Drexel University | Recruiting | Philadelphia | Pennsylvania | 19104 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36879078 | Derived | Butler RM, Lampe E, Trainor C, Manasse SM. Fear of weight gain during cognitive behavioral therapy for binge-spectrum eating disorders. Eat Weight Disord. 2023 Mar 6;28(1):29. doi: 10.1007/s40519-023-01541-8. |
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| ID | Term |
|---|---|
| D056912 | Binge-Eating Disorder |
| D052018 | Bulimia Nervosa |
| ID | Term |
|---|---|
| D001068 | Feeding and Eating Disorders |
| D001523 | Mental Disorders |
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Participants will be randomly assigned to the ICT or ICT sham condition.
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The investigators, therapists, and graduate student assessors will be blinded to treatment condition. The only staff member who cannot be blinded to condition is the study coordinator; she will be aware of condition because of managing randomization and assisting participants in the downloading of the intervention to participants' computers.
| ICT |
| Behavioral |
Participants will complete 4 weeks of daily inhibitory control trainings and "booster" ICT trainings following CBT treatment in weeks 5-12 |
|
An ecologically valid measure of inhibitory control specific to eating behavior, this task measures the amount of food that a participant consumes during a 10min interval when asked to taste the food presented
| Change from baseline to post-treatment and 3-month follow up |