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People utilize two behavioral strategies, goal-directed and habitual, when engaging in value-based decision-making that involves rewarding or punishing outcomes. Accumulating evidence suggests an imbalance between habitual and goal-directed behavior in favor of habitual control in parallel with exaggerated tendency toward compulsive/harm avoidance behavior in OCD. In healthy subjects, an arbitration mechanism has been proposed recently that controls the balance between those two strategies of action selection. Arbitration regions regulate the goal-directed/habitual decision-making balance by selectively downregulating the activity of the habitual regions. This project aims to explore the neurobehavioral characteristics of arbitration mechanism and its relationship with behaviors and clinical phenotypes in OCD by applying computational cognitive neuroscience, clinical task-based functional magnetic resonance imaging (fMRI) and transcranial direct current stimulation (tDCS) method.
Investigators will recruit 30 male and female adults (age 18-65) with OCD and 30 age-, sex-, and education-matched healthy (medically, neurologically and psychiatrically) controls for this project. Each participant will come for three sessions. There will be 3-4 days interval between sessions:
Session 1 that includes initial clinical assessment and obtaining T1 structural image (needed for neuronavigation analysis and electric field modeling).
Session 2 and 3 that include performing two separate decision-making and symptom provocation-avoidance tasks by participants with OCD and healthy controls under two conditions: while scanned inside the MRI scanner (no tDCS) or while receiving neuronavigated tDCS neurostimulation outside the scanner (no fMRI imaging). As participates will perform each task twice, there might be an order effect on task performance. For minimizing the impact of such a potential order effect on imaging and tDCS results, participants will be randomly assigned to undergo scanning in the session 2 and then receive tDCS in the session 3 or in the opposite order (tDCS in session 2 and then imaging in session 3) but in each session only one of imaging or tDCS experiments (for both tasks) will be conducted for each participant. OCD-relevant and aversive picture rating (explained below) will be done always in the session 3 as the last experiment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy subjects | Active Comparator |
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| OCD subjects | Active Comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| transcranial Direct Current Stimulation (tDCS) | Device | tDCS is a non-invasive brain stimulation method by which constant low direct current can be delivered to the sculpt for changing the excitability of neuronal structure adjunct to the stimulating electrode. |
| Measure | Description | Time Frame |
|---|---|---|
| Strength of Behaving Model-based (Goal-directed) | Strength of behaving model-based (goal-directed) is measured and quantifiedas a continuous real number between 0 and 1. Here, having a strength's valueof 1 of behaving model-based means that subject in her/his decision-making,exclusively and always utilizes a model-based (goal-directed) strategy fordecision making and having a value of Zero means not utilizing model-based(goal-directed) strategy at all when decising. | On the second or third session when subjects performed the task in the MRI scanner. |
| Reaction Time in Response to Stimuli With OCD Themes | This is a time interval (in seconds) between the start of presentation of visual stimuli with OCD themes and when subjects pushed a bottom to stop the presentation when they could not tolerate those more during symptom provocation and avoidance task. | On the second or third session when subjects performed the task in the MRI scanner. |
| Strength of Frontal Arbitration Modulation of Basal Ganglia Habit Region. | Here, by applying Dynamic Causal Modeling (DCM) method, we measured thestrength of frontal arbitration (the interior frontal gyrus (IFG)) modulation ofbasal ganglia habit region (the posterolateral putamen) in terms of the effective(directed) connectivity between the interior frontal gyrus (IFG) andposterolateral putamen. This DCM-based effective connectivity can have avalue between -1 and +1. A value of -1 means a maximum effective connectivitybetween the interior frontal gyrus (IFG) and posterolateral putamen. A value of+1 means maximum excitatory effective connectivity between the interior frontalgyrus (IFG) and posterolateral putamen. And a value of 0 means no effectiveconnectivity between the interior frontal gyrus (IFG) and posterolateralputamen. | On the second or third session when subjects performed the task in the MRI scanner |
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A) OCD participants inclusion criteria:
B) OCD participants exclusion criteria:
C) Healthy control inclusion criteria:
1-males and females age 18-65 years with signed informed consent and IQ greater than 80 on WASI.
D) Exclusion criteria for all participants:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UCLA | Los Angeles | California | 90095 | United States |
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| ID | Title | Description |
|---|---|---|
| FG000 | Healthy Subjects: fMRI Imaging First, Then tDCS | Healthy control subjects who first underwent imaging experiments in which they performed tasks in the MRI scanner on their second visit (no brain stimulation) and on the third session, performed the same tasks when receiving brain stimulation by tDCS (no imaging). |
| FG001 |
| Title | Milestones | Reasons Not Completed | |||||
|---|---|---|---|---|---|---|---|
| First Intervention (4 Days) |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Sep 20, 2018 |
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| Healthy Subjects:tDCS First, Then fMRI Imaging |
Healthy control subjects that first performed the two tasks when receiving brain stimulation by tDCS (no imaging) on their second visit and on the third session performed the same tasks in the MRI scanner (no brain stimulation). |
| FG002 | OCD Subjects: fMRI Imaging First, Then tDCS | OCD subjects who first underwent imaging experiments in which they performed tasks in the MRI scanner on their second visit (no brain stimulation) and on the third session, performed the same tasks when receiving brain stimulation by tDCS (no imaging). |
| FG003 | OCDSubjects: tDCS First, Then fMRI Imaging | OCD control subjects that first performed the two tasks when receiving brain stimulation by tDCS (no imaging) on their second visit and on the third session performed the same tasks in the MRI scanner (no brain stimulation). |
| COMPLETED |
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| NOT COMPLETED |
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| Second Intervention (4 Days) |
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| ID | Title | Description |
|---|---|---|
| BG000 | Healthy Subjects: fMRI Imaging First, Then tDCS | Healthy control subjects who first underwent imaging experiments in which they performed tasks in the MRI scanner on their second visit (no brain stimulation) and on the third session, performed the same tasks when receiving brain stimulation by tDCS (no imaging). A) Healthy control inclusion criteria: 1-Males and females age 18-65 years fluent English speaker with signed informed consent. B) Exclusion criteria for control participants:
|
| BG001 | Healthy Subjects: tDCS First, Then fMRI Imaging | Healthy control subjects that first performed the two tasks when receiving brain stimulation by tDCS (no imaging) on their second visit and on the third session performed the same tasks in the MRI scanner (no brain stimulation). A) Healthy control inclusion criteria: 1-Males and females age 18-65 years fluent English speaker with signed informed consent. B) Exclusion criteria for control participants:
|
| BG002 | OCD Subjects: fMRI Imaging First, Then tDCS | OCD subjects who first underwent imaging experiments in which they performed tasks in the MRI scanner on their second visit (no brain stimulation) and on the third session, performed the same tasks when receiving brain stimulation by tDCS (no imaging). A) OCD participants inclusion criteria:
B) OCD participants exclusion criteria:
C) Exclusion criteria for OCD participants:
|
| BG003 | OCD Subjects: tDCS First, Then fMRI Imaging | OCD control subjects that first performed the two tasks when receiving brain stimulation by tDCS (no imaging) on their second visit and on the third session performed the same tasks in the MRI scanner (no brain stimulation). A) OCD participants inclusion criteria:
B) OCD participants exclusion criteria:
C) Exclusion criteria for OCD participants:
|
| BG004 | Total | Total of all reporting groups |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants | Participants | No |
| |||||||||||||||
| Age, Continuous | Mean | Full Range | year |
| |||||||||||||||
| Sex: Female, Male | Count of Participants | Participants | No |
| |||||||||||||||
| Ethnicity (NIH/OMB) | Count of Participants | Participants | No |
| |||||||||||||||
| Race (NIH/OMB) | Count of Participants | Participants | No |
| |||||||||||||||
| Region of Enrollment | Count of Participants | Participants | No |
|
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Strength of Behaving Model-based (Goal-directed) | Strength of behaving model-based (goal-directed) is measured and quantifiedas a continuous real number between 0 and 1. Here, having a strength's valueof 1 of behaving model-based means that subject in her/his decision-making,exclusively and always utilizes a model-based (goal-directed) strategy fordecision making and having a value of Zero means not utilizing model-based(goal-directed) strategy at all when decising. | Posted | Mean | Standard Deviation | units on a scale | On the second or third session when subjects performed the task in the MRI scanner. |
|
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| Primary | Reaction Time in Response to Stimuli With OCD Themes | This is a time interval (in seconds) between the start of presentation of visual stimuli with OCD themes and when subjects pushed a bottom to stop the presentation when they could not tolerate those more during symptom provocation and avoidance task. | Posted | Mean | Standard Deviation | seconds | On the second or third session when subjects performed the task in the MRI scanner. |
| |||||||||||||||||||||||||||||||||||||
| Primary | Strength of Frontal Arbitration Modulation of Basal Ganglia Habit Region. | Here, by applying Dynamic Causal Modeling (DCM) method, we measured thestrength of frontal arbitration (the interior frontal gyrus (IFG)) modulation ofbasal ganglia habit region (the posterolateral putamen) in terms of the effective(directed) connectivity between the interior frontal gyrus (IFG) andposterolateral putamen. This DCM-based effective connectivity can have avalue between -1 and +1. A value of -1 means a maximum effective connectivitybetween the interior frontal gyrus (IFG) and posterolateral putamen. A value of+1 means maximum excitatory effective connectivity between the interior frontalgyrus (IFG) and posterolateral putamen. And a value of 0 means no effectiveconnectivity between the interior frontal gyrus (IFG) and posterolateralputamen. | Posted | Mean | Standard Deviation | units on ascale | On the second or third session when subjects performed the task in the MRI scanner |
|
4 years and six months.
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Healthy Subjects: fMR Imaging | This was during the sessions when subjects performed tasks in MRI scanner. | 0 | 30 | 0 | 30 | 0 | 30 |
| EG001 | Healthy Subjects: tDCS | This was during the sessions when subjects performed tasks with brain stimulation (tDCS). | 0 | 30 | 0 | 30 | 0 | 30 |
| EG002 | OCD Subjects: fMRI Imaging | This was during the sessions when subjects performed tasks in MRI scanner. | 0 | 30 | 0 | 30 | 0 | 30 |
| EG003 | OCD Subjects:tDCS | This was during the sessions when subjects performed tasks with brain stimulation (tDCS). | 0 | 30 | 0 | 30 | 0 | 30 |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Reza Tadayon Nejad | UCLA | 3102066389 | rtadayonnejad@mednet.ucla.edu |
| Jul 27, 2025 |
| Prot_SAP_001.pdf |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |
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| Between 18 and 65 years |
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| >=65 years |
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| Male |
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| Not Hispanic or Latino |
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| Unknown or Not Reported |
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| Asian |
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| Native Hawaiian or Other Pacific Islander |
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| Black or African American |
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| White |
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| More than one race |
|
| Unknown or Not Reported |
|
| OG002 | OCD Subjects: fMRI Imaging First, Then tDCS | OCD subjects who first underwent imaging experiments in which they performed tasks in the MRI scanner on their second visit (no brain stimulation) and on the third session, performed the same tasks when receiving brain stimulation by tDCS (no imaging). A) OCD participants inclusion criteria:
B) OCD participants exclusion criteria:
C) Exclusion criteria for OCD participants:
|
| OG003 | OCD Subjects: tDCS First, Then fMRI Imaging | OCD control subjects that first performed the two tasks when receiving brain stimulation by tDCS (no imaging) on their second visit and on the third session performed the same tasks in the MRI scanner (no brain stimulation). A) OCD participants inclusion criteria:
B) OCD participants exclusion criteria:
C) Exclusion criteria for OCD participants:
|
|
|
| OG001 | Healthy Subjects: tDCS First, Then fMRI Imaging | Healthy control subjects that first performed the two tasks when receiving brain stimulation by tDCS (no imaging) on their second visit and on the third session performed the same tasks in the MRI scanner (no brain stimulation). A) Healthy control inclusion criteria: 1-Males and females age 18-65 years fluent English speaker with signed informed consent. B) Exclusion criteria for control participants:
|
| OG002 | OCD Subjects: fMRI Imaging First, Then tDCS | OCD subjects who first underwent imaging experiments in which they performed tasks in the MRI scanner on their second visit (no brain stimulation) and on the third session, performed the same tasks when receiving brain stimulation by tDCS (no imaging). A) OCD participants inclusion criteria:
B) OCD participants exclusion criteria:
C) Exclusion criteria for OCD participants:
|
| OG003 | OCD Subjects: tDCS First, Then fMRI Imaging | OCD control subjects that first performed the two tasks when receiving brain stimulation by tDCS (no imaging) on their second visit and on the third session performed the same tasks in the MRI scanner (no brain stimulation). A) OCD participants inclusion criteria:
B) OCD participants exclusion criteria:
C) Exclusion criteria for OCD participants:
|
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