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This is an observational study to examine the cardiovascular mechanisms of increased cardiovascular mortality in those with high activity occupations.
The current proposal uses a repeated-measures, within-subject design to address our aims. Twenty male participants will report to the laboratory to provide informed consent, complete baseline assessments, and receive ambulatory monitors. Following this session, each participant will wear physical activity and ambulatory cardiovascular monitors for 7 days, including at least one non-work day and one work day. Characterization of work activity will use physical activity data from self-reported time at work (Specific Aim I). The 24-hour cardiovascular load (HR and BP) and nocturnal HRV will be compared across work and non-work days (Specific Aim II). Lastly, whether fitness level or job strain modify the difference in cardiovascular strain between work vs. non-work days will be evaluated (Specific Aim III).
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| Measure | Description | Time Frame |
|---|---|---|
| 24-hour Heart Rate | We will calculate the average heart rate over each 24 hour period throughout a one week monitoring period. | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| 24-hour Ambulatory Systolic Blood Pressure | We will calculate the average systolic blood pressure over a 24-hour period on two separate days (workdays versus non-workdays). | 24 hours |
| Nocturnal Heart Rate Variability, RMSSD |
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Inclusion Criteria:
Exclusion Criteria:
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Only males are eligible for this study.
Middle-aged male food service workers
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| Name | Affiliation | Role |
|---|---|---|
| Tyler D Quinn, MS | Graduate Student | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Physical Activity and Weight Management Research Laboratory | Pittsburgh | Pennsylvania | 15261 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38955811 | Derived | Quinn TD, Bruehwiler T, Chantler PD, Gibbs BB. Cardiovascular Responses to Occupational Physical Activity Are Exaggerated by Work-Related Stress and Low Fitness. J Occup Environ Med. 2024 Oct 1;66(10):e476-e482. doi: 10.1097/JOM.0000000000003183. Epub 2024 Jul 1. |
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Upon completion of all data collection, data will be analyzed and summary conclusions will be published in a peer reviewed scientific journal.
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| ID | Title | Description |
|---|---|---|
| FG000 | Middle-aged Males in High Activity Occupations | All participants were enrolled into a single arm and all comparisons were made within subjects. |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
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| ID | Title | Description |
|---|---|---|
| BG000 | Research Study Participation | Participants who were enrolled in the study and completed all study procedures. |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | 24-hour Heart Rate | We will calculate the average heart rate over each 24 hour period throughout a one week monitoring period. | Posted | Least Squares Mean | Standard Error | beats per minute | 24 hours |
|
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1 week
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Research Study Participation | Participants who were enrolled in the study and completed all study procedures. |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr. Tyler Quinn | Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health | 412-386-4450 | yhh7@cdc.gov |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP_ICF | Yes | Yes | Yes | Study Protocol, Statistical Analysis Plan, and Informed Consent Form | Sep 26, 2019 | Apr 6, 2021 | Prot_SAP_ICF_000.pdf |
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| ID | Term |
|---|---|
| D009784 | Occupational Diseases |
| D002318 | Cardiovascular Diseases |
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We will calculate the average heart rate variability during each night's sleep for a total of one week. The specific HRV variable presented is root mean square successive differences (RMSSD).
| approximately 8 hours (sleep time) |
| Physical Activity Pattern. Steps Per Day | This physical activity metric of steps per day was calculated as average number of steps during each day type (work versus non-workdays) throughout one week | 1 week |
| Nocturnal Heart Rate Variability, SDNN | We will calculate the average heart rate variability during each night's sleep for a total of one week. The specific HRV variable presented is standard deviation of the normal to normal RR intervals (SDNN). | approximately 8 hours (sleep time) |
| Nocturnal Heart Rate Variability, LF | We will calculate the average heart rate variability during each night's sleep for a total of one week. The specific HRV variable presented is low frequency power (LF). | approximately 8 hours (sleep time) |
| Nocturnal Heart Rate Variability, HF | We will calculate the average heart rate variability during each night's sleep for a total of one week. The specific HRV variable presented is high frequency power (HF). | approximately 8 hours (sleep time) |
| Physical Activity Pattern. MVPA | This physical activity metric of minutes of moderate to vigorous physical activity was calculated as average minutes during each day type (work versus non-workdays) throughout one week | 1 week |
| Physical Activity Pattern. LPA | This physical activity metric of minutes of light physical activity was calculated as average minutes during each day type (work versus non-workdays) throughout one week | 1 week |
| Physical Activity Pattern. Sedentary | This physical activity metric of minutes of sedentary time was calculated as average minutes during each day type (work versus non-workdays) throughout one week | 1 week |
| Physical Activity Pattern. Upright | This physical activity metric of minutes of upright time was calculated as average minutes during each day type (work versus non-workdays) throughout one week | 1 week |
| 24-hour Ambulatory Diastolic Blood Pressure | We will calculate the average diastolic blood pressure over a 24-hour period on two separate days (workdays versus non-workdays). | 24 hours |
| years |
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| Sex: Female, Male | Count of Participants | Participants |
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| Race (NIH/OMB) | Count of Participants | Participants |
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| Region of Enrollment | Number | participants |
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| Occupational Industry | Count of Participants | Participants |
|
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| Secondary | 24-hour Ambulatory Systolic Blood Pressure | We will calculate the average systolic blood pressure over a 24-hour period on two separate days (workdays versus non-workdays). | Posted | Least Squares Mean | Standard Error | millimeters of Mercury | 24 hours |
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| Secondary | Nocturnal Heart Rate Variability, RMSSD | We will calculate the average heart rate variability during each night's sleep for a total of one week. The specific HRV variable presented is root mean square successive differences (RMSSD). | Posted | Least Squares Mean | Standard Error | milliseconds | approximately 8 hours (sleep time) |
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| Secondary | Physical Activity Pattern. Steps Per Day | This physical activity metric of steps per day was calculated as average number of steps during each day type (work versus non-workdays) throughout one week | Posted | Least Squares Mean | Standard Error | steps per day | 1 week |
|
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| Secondary | Nocturnal Heart Rate Variability, SDNN | We will calculate the average heart rate variability during each night's sleep for a total of one week. The specific HRV variable presented is standard deviation of the normal to normal RR intervals (SDNN). | Posted | Least Squares Mean | Standard Error | milliseconds | approximately 8 hours (sleep time) |
|
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|
| Secondary | Nocturnal Heart Rate Variability, LF | We will calculate the average heart rate variability during each night's sleep for a total of one week. The specific HRV variable presented is low frequency power (LF). | Posted | Least Squares Mean | Standard Error | log milliseconds | approximately 8 hours (sleep time) |
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| Secondary | Nocturnal Heart Rate Variability, HF | We will calculate the average heart rate variability during each night's sleep for a total of one week. The specific HRV variable presented is high frequency power (HF). | Posted | Least Squares Mean | Standard Error | log milliseconds | approximately 8 hours (sleep time) |
|
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| Secondary | Physical Activity Pattern. MVPA | This physical activity metric of minutes of moderate to vigorous physical activity was calculated as average minutes during each day type (work versus non-workdays) throughout one week | Posted | Least Squares Mean | Standard Error | minutes per day | 1 week |
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| Secondary | Physical Activity Pattern. LPA | This physical activity metric of minutes of light physical activity was calculated as average minutes during each day type (work versus non-workdays) throughout one week | Posted | Least Squares Mean | Standard Error | minutes per day | 1 week |
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| Secondary | Physical Activity Pattern. Sedentary | This physical activity metric of minutes of sedentary time was calculated as average minutes during each day type (work versus non-workdays) throughout one week | Posted | Least Squares Mean | Standard Error | minutes per day | 1 week |
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| Secondary | Physical Activity Pattern. Upright | This physical activity metric of minutes of upright time was calculated as average minutes during each day type (work versus non-workdays) throughout one week | Posted | Least Squares Mean | Standard Error | minutes per day | 1 week |
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| Secondary | 24-hour Ambulatory Diastolic Blood Pressure | We will calculate the average diastolic blood pressure over a 24-hour period on two separate days (workdays versus non-workdays). | Posted | Least Squares Mean | Standard Error | millimeters of Mercury | 24 hours |
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