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In this study, the investigators detected the expression of SREBP1 in thyroid cancer tissues, explored the biological functions of SREBP1 in thyroid cancer cells.
qRT-PCR and immunohistochemistry were used to detect the expression of SREBP1 in 96 pairs thyroid cancer tissues and the adjacent normal tissues. The following methods, including the MTS, colony-forming assay, flow cytometry and hoechst staining were used to detect the biological function of thyroid cancer cells based on SREBP1 interference or not.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| thyroid cancer | the thyroid cancer was determined by the the Pathology Department based on the pathological evidence. |
| |
| the adjacent thyroid tissues | the adjacent thyroid tissues was collected from the tissue that 3 centimeters from the thyroid cancer. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| pathologic | Other | All the enrolled patients were treated with whole resection and diagnosed by the Pathology Department based on the pathological evidence. |
|
| Measure | Description | Time Frame |
|---|---|---|
| progression-free survival | disease recurrent of progression | average 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| theraputic efficacy | According to the ATA guideline, patients were divided into four group, including excellent response (ER),indeterminate response (IDR), biochemical incomplete response (BIR), structural incomplete response (SIR) after surgery and radioiodine treatment. | average 18 months |
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Inclusion Criteria:
Clinical diagnosis of thyroid cancer Reciving thyroidectomy surgery No experience of radiation therapy Nice treatment compliance and follow-up regularly
Exclusion Criteria:
Prior history of malignancy ; Radiotherapy history, chemotherapy history; Serious concomitant diseases ; Chronic renal insufficiency and liver dysfunction
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all of this patients were recruited from the Affiliated Cancer Hospital of Xiangya Medical School
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| Name | Affiliation | Role |
|---|---|---|
| Zhi Li, Prof. | Central South University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| the Affiliated Cancer Hospital of Xiangya Medical School | Changsha | Hunan | 410078 | China |
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| ID | Term |
|---|---|
| D013964 | Thyroid Neoplasms |
| ID | Term |
|---|---|
| D004701 | Endocrine Gland Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D006258 | Head and Neck Neoplasms |
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| ID | Term |
|---|---|
| C000614965 | Iodine-131 |
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Tissue samples were snap-frozen and stored in liquid nitrogen immediately after surgery.
|
| D004700 |
| Endocrine System Diseases |
| D013959 | Thyroid Diseases |