Gut Microbiota, Anastomotic Leak and Colorectal Cancer

Gut Microbiota, Anastomotic Leak and Colorectal Cancer

This is a prospective study evaluating the relation between the gut microbiota composition, intestinal healing after colorectal surgery and colorectal cancer behavior.

Our hypothesis is that the gut microbiota composition could predict poor intestinal healing in colorectal surgery, and that the gut microbiota might have an impact on colorectal cancer clinical behavior and may predict disease outcomes.

No more details required

Inclusion Criteria:

• Age 18 years and older
• CRC diagnosis
• Upcoming colonic and/or rectal resection with/without anastomosis
• Individuals without diseases of the colon and rectum (healthy controls)

Exclusion Criteria:

• Pregnancy
• Previous stoma
• Bowel surgery in the last 4 weeks prior to the surgery

Secondary objectives, inclusion criteria are as follows:

• Age 18 years and older
• Rectal cancer diagnosis with histopathological confirmation
• Abdominoperineal resection with terminal colostomy
• Expectative non-surgical management ("Watch and wait approach")