Laser Therapy on Orthodontic Tooth Movement | NCT04070170

NCT04070170

Protocol Section

Identification Module

Results Section

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No data is available for this block.

Annotation Section

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Document Section

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Derived Section

Miscellaneous Info Module

Status Module

Oversight Module

Description Module

Design Module

Interventional Study Design

Biospecimen

No data available

No data is available for this block.

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Low-level laser therapy and no orthodontic force	Experimental	No orthodontic force. Laser is applied on the first day and the premolars is extracted after 24 hours	Device: Low-level Laser Therapy
Low-level laser therapy and application of orthodontic force	Experimental	Orthodontic force and Laser is applied on the first day and the premolars is extracted after 24 hours	Device: Low-level Laser Therapy Procedure: Orthodontic force
Orthodontic force only	Active Comparator	Orthodontic force is applied and the premolars is extracted after 24 hours, with no laser therapy	Procedure: Orthodontic force
Low-level laser therapy and orthodontic force	Experimental	Orthodontic force and Laser is applied and the orthodontic tooth movement is evaluated	Device: Low-level Laser Therapy Procedure: Orthodontic force
Orthodontic force with no laser therapy	Active Comparator	Orthodontic force is applied and the orthodontic tooth movement is evaluated, with no laser therapy

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Low-level Laser Therapy	Device	Low-level laser therapy is applied on premolars that will be extracted for treatment plan reasons	Low-level laser therapy and application of orthodontic force

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Rate of orthodontic tooth movement, with and without low-level laser therapy	The canine retraction was measured with a digital dynamometer	The quantification of OTM was performed before canine retraction
Rate of orthodontic tooth movement, with and without low-level laser therapy	The canine retraction was measured with a digital dynamometer	The quantification of OTM was performed after 1 month of canine retraction
Rate of orthodontic tooth movement, with and without low-level laser therapy	The canine retraction was measured with a digital dynamometer	The quantification of OTM was performed after 2 months of canine retraction
Rate of orthodontic tooth movement, with and without low-level laser therapy	The canine retraction was measured with a digital dynamometer	The quantification of OTM was performed after 3 months of canine retraction

Secondary Outcomes

Measure	Description	Time Frame
Chemokine levels in the periodontal tissue after LLLT and orthodontic force	The chemokine levels were measured in the periodontal tissue after LLLT and orthodontic force by means of a cytometric bead array (CBA)	The chemokine levels were assayed on days 0, 1, 7 and 14 after application of orthodontic force and low-level laser therapy

Eligibility Module

Contacts/Locations Module

Facility	Status	City	State	ZIP	Country	Contacts
Pontifical Catholic University of Minas Gerais		Belo Horizonte	Minas Gerais	30535-901	Brazil

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
22381489	Background	Doshi-Mehta G, Bhad-Patil WA. Efficacy of low-intensity laser therapy in reducing treatment time and orthodontic pain: a clinical investigation. Am J Orthod Dentofacial Orthop. 2012 Mar;141(3):289-297. doi: 10.1016/j.ajodo.2011.09.009.
10505748	Background	Alhashimi N, Frithiof L, Brudvik P, Bakhiet M. Chemokines are upregulated during orthodontic tooth movement. J Interferon Cytokine Res. 1999 Sep;19(9):1047-52. doi: 10.1089/107999099313271.

IPD Sharing Statement Module