Effectiveness of CGA on QoL in Older Patients With Cancer Receiving Systemic Therapy

The Effectiveness of Patient Coaching Within the Comprehensive Geriatric Assessment Process on Quality of Life in Older Patients With Cancer Receiving Systemic Therapy: a Multicenter Randomized Controlled Trial

The G-oncoCOACH study aims to evaluate the effectiveness of the Comprehensive Geriatric Assessment (CGA) process coordinated by a geriatric team in combination with intensive patient coaching compared to the current standard of care, which is CGA coordinated by an oncology team.

The G-oncoCOACH study aims to evaluate the effectiveness of the Comprehensive Geriatric Assessment (CGA) process coordinated by a geriatric team in combination with intensive patient coaching compared to the current standard of care, which is CGA coordinated by an oncology team. The Medical Research Council (MRC) Framework, developed to test complex interventions, is used to design this study. A multicenter randomized controlled trial will be conducted in two academic hospitals (UZ Brussel - UZ Leuven) with a follow-up at 3, 6 and 12 months after the start of systemic therapy. Patients will be recruited in both academic hospitals in the period between the cancer diagnosis and the start of the systemic therapy.

Inclusion Criteria:

• patients aged 70 years and older

• diagnosis of cancer (solid tumors)

• starting systemic therapy (chemotherapy, immunotherapy, targeted therapy or hormonal therapy)

  • curative intent (neo-adjuvant / adjuvant / concomitant / other)
  • palliative intent (first line / second line)

• patients must be able to comply with the study procedures

• physician-estimated life expectancy must be more than 6 months

Exclusion Criteria:

• patients with antihormonal monotherapy
• previous participation in geriatric intervention studies
• patients included in clinical trials with non-registered anticancer drugs