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The purpose of this study is to collect clinical data, blood samples, and self reported symptoms of peripheral neuropathy from Chinese patients with breast cancer after treatment with taxanes. This data will be used to develop predictive markers for neuropathy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with CIPN | Patients with peripheral neuropathy after treatment with taxanes |
| |
| Patients without CIPN | Patients treated with taxanes and don't develop will be enrolled to this cohort and matched to a specified subject with neurotoxicity based on age, tumor stage, chemotherapy regimen or total taxane dosage |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Patient Questionnaires | Other | FACT-Ntx, EORTC-CIPN20 |
|
| Measure | Description | Time Frame |
|---|---|---|
| Total score from the FACT-GOG-Ntx questionnaire | Total score from the FACT-GOG-Ntx questionnaire for peripheral neuropathy, ranging from 0-44,higher value represents a worse outcome | Up to 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Predictive value of genetic variants for the development of neuropathy | SNPs related to peripheral neuropathy | In the two weeks before start treatment |
| Total score from the EORTC QLQ - CIPN20 questionnaire |
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Inclusion Criteria:
Exclusion Criteria:
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Chinese breast cancer patients treated with taxanes
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hongnan Mo, MD | Contact | +86-10-87788200 | mhnzlyynk@outlook.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cancer Hospital, Chinese Academy of Medical Sciences | Recruiting | Beijing | Beijing Municipality | 100021 | China |
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| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Whole blood, DNA,Peripheral Blood Mononuclear Cells (PBMC)
| Blood Collection | Other | biomarker analysis |
|
Total score from the EORTC QLQ - CIPN20 questionnaire for peripheral neuropathy, ranging from 20-80,higher value represents a worse outcome
| Up to 2 years |
| D017437 |
| Skin and Connective Tissue Diseases |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |