Gas Exchange and CT Effects of PEEP in ARDS | NCT04067154 | Trialant

Gas Exchange and CT Effects of PEEP in ARDS | NCT04067154 | Trialant

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
ALPE-TAC	Experimental	ARDS patients on mechanical ventilation. Measurement of CT scan at PEEP of 5, 20 and 45 cm H2O to evaluate potential for recruitment and measurement of gas exchange by model-based method and FiO2 titration at PEEP of 5 and 20 cm H2O	Diagnostic Test: ALPE

Interventions

Name	Type	Description	Arm Group Labels	Other Names
ALPE	Diagnostic Test	Measurement of CT scan at PEEP of 5, 20 and 45 cm H2O Measurement of gas exchange by model-based method and FiO2 titration at PEEP of 5 and 20 cm H2O	ALPE-TAC

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Gas Exchange and lung recruitability at diferent PEEP levels	Gas exchange (At PEEP 5 and 20 cm H2O), CT scan (At PEEP 5, 20 and 45 cm H2O)	Approximately two hours

Secondary Outcomes

Measure	Description	Time Frame
Physiologic Parameter 1	Hemodynamic assessment at different PEEP levels	Approximately two hours
Physiologic Parameter 2	Respiratory mechanics at different PEEP levels

Contacts/Locations Module

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
32293506	Derived	Karbing DS, Panigada M, Bottino N, Spinelli E, Protti A, Rees SE, Gattinoni L. Changes in shunt, ventilation/perfusion mismatch, and lung aeration with PEEP in patients with ARDS: a prospective single-arm interventional study. Crit Care. 2020 Mar 23;24(1):111. doi: 10.1186/s13054-020-2834-6.