This study aims to evaluate the pharmacokinetic interaction between tegoprazan and combination of metronidazole, tetracycline and bismuth in healthy adult volunteers.

A open-label, randomized, multiple dose, two arm, two period, crossover study

Inclusion Criteria:

• Healthy adult aged ≥ 19 and < 55 year-old on the day of obtaining the informed consent.
• Body mass index (BMI) ≥ 17.5 kg/m2 and < 28.0 kg/m2 with a body weight ≥ 55 kg at screening.
• H. pylori negative.

Exclusion Criteria:

• Medical History

  1. History or evidence of clinically significant disease
  2. History of gastrointestinal disease (e.g., esophageal disease such as esophageal achalasia or stenosis, and Crohn's disease) or surgery that may affect the absorption of a drug.
  3. History or presence of hypersensitivity to IMPs, components of IMPs, benzimidazoles, imidazole derivatives or tetracycline antibiotics

• Laboratory tests(in blood)

  1) Total bilirubin, AST (GOT), ALT (GPT) > 1.5 X upper limit of normal (ULN) at screening

• History of drug/alcohol abuse

• Participated in other study and received investigational product within 3 months prior to the first study dose.

• taken a medication known to substantially induce or inhibit a drug metabolizing enzyme

• Not able to use a medically acceptable contraceptive method throughout the study.