Compare Sudden Stopping and Weaning of Anticholinergics in Recurrence of OAB Symptoms

Recurrence of Symptoms of Overactive Bladder After Weaning Versus Sudden Stopping of Anticholinergics

Our study included 60 patients with idiopathic OAB and treated with solifenacin 5mg twice daily for one month. After improvement of their condition, we divided the responders into 2 groups, group I stopped the drug suddenly, while group II underwent gradual weaning of the drug.

We started an open-label, prospective, two-arm, randomized controlled trial at Beni-Suef University, from January 2018 to January 2019, including 60 patients suffering from OAB symptoms. Patients were recently diagnosed with idiopathic OAB which was not treated prior to enrollment. All participants signed written informed consents. The study protocol was approved by the ethics committee of our faculty. Patients were allocated into 2 equal groups (30 patients in each group) according to a computer-generated random numeric table after exclusion of those who are not eligible or refused to be included in the study

Inclusion Criteria:

• OAB patients.
• Recently diagnosed.

Exclusion Criteria:

• Previous trials of treatment
• UTI, stones, tumors, or Infravesical obstruction.