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| Name | Class |
|---|---|
| University of Copenhagen | OTHER |
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The overall objective of this study is to investigate whether hypoglycaemia (the most potent stimulus of pancreatic glucagon secretion) affects the secretion of gut-derived glucagon in totally pancreatectomized patients.
The investigators want to assess the plasma glucagon response to insulin-induced hypoglycaemia in totally pancreatectomised patients and at the same time evaluate whether hypoglycaemia affects a range of other products from endocrine cells in the gastrointestinal tract including ghrelin, gastrin, cholecystokinin (CCK), glucose-dependent insulinotropic polypeptide (GIP), GLP-1, glucagon-like peptide-2 (GLP-2), oxyntomodulin and peptide YY (PYY). Furthermore the investigators will evaluate how hypoglycaemia in these patients affects other counter-regulatory mechanisms including plasma responses of the hormones adrenaline, noradrenaline, growth hormone and cortisol as well as the rate of gastric emptying rate (which under normal circumstances accelerates during hypoglycaemia) during an oral glucose tolerance test (OGTT).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Totally pancreatectomized patients | Experimental | Oral glucose tolerance test + insulin-induced hypoglycaemic clamp followed by an oral glucose tolerance test |
|
| Healthy controls | Experimental | Oral glucose tolerance test + insulin-induced hypoglycaemic clamp followed by an oral glucose tolerance test |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oral glucose tolerance test | Other | 50 grams OGTT |
|
| Measure | Description | Time Frame |
|---|---|---|
| p-glucagon | Plasma glucagon excursions measured as incremental area under the curve (iAUC) | -30, -15, 0, 15, 40, 50, 60, 70, 80, 90, 105, 120, 135, 150, 165, 180, 210, 240 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| p-glucose | plasma glucose excursions measured as incremental area under the curve (iAUC) | -30, -15, 0, 15, 40, 50, 60, 70, 80, 90, 105, 120, 135, 150, 165, 180, 210, 240 minutes |
| GIP, GLP-1, GLP-2, GIP, oxyntomodulin, ghrelin, peptide YY, gastrin |
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Inclusion Criteria:
Pancreatectomised patients
Exclusion Criteria:
Pancreatectomised patients
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Center for Clinical Metabolic Research | Hellerup | Capital Region | 2900 | Denmark |
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| ID | Term |
|---|---|
| D005951 | Glucose Tolerance Test |
| ID | Term |
|---|---|
| D001774 | Blood Chemical Analysis |
| D019963 | Clinical Chemistry Tests |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
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12 totally pancreatectomized patients and 12 healthy control subjects
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| Clamp experiment | Other | insulin-induced hypoglycaemic clamp followed by an 50 grams OGTT |
|
excursions in Gut hormones measured as incremental area under the curve (iAUC)
| -30, -15, 0, 15, 40, 50, 60, 70, 80, 90, 105, 120, 135, 150, 165, 180, 210, 240 minutes |
| catecholamines | p-adrenaline and p-noradrenaline, excursions measured as incremental area under the curve (iAUC) | -30, -15, 0, 15, 40, 50, 60, 70, 80, 90 minutes |
| cortisol | p-cortisol excursions measured as incremental area under the curve (iAUC) | -30, -15, 0, 15, 40, 50, 60, 70, 80, 90 minutes |
| growth hormone | p-growth hormone excursions measured as incremental area under the curve (iAUC) | -30, -15, 0, 15, 40, 50, 60, 70, 80, 90 minutes |
| D003933 | Diagnosis |
| D003940 | Diagnostic Techniques, Endocrine |
| D008919 | Investigative Techniques |