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The study is a prospective observational study where participants will be recruited from the Ophthalmology department (Outpatient department, Eye Casualty). Only one research visit will be required. Participants will be asked to fill in a set of questionnaires (Visual Functioning Questionnaire-15(61), Low Luminance Questionnaire(62)) assessing their quality of life and vision and their full medical history will be collected. Then they will have their contrast sensitivity tested under various light conditions. If a recent visual field test is not available, that might be performed as part of the study.
The purpose of our, real world study is to explore contrast sensitivity differences after changes in ambient light setting in patients with glaucoma compared with controls (patients with ocular hypertension). Participants will be asked to read a Pelli- Robson chart under photopic (bright light conditions) and mesopic (intermediate light conditions); followed by scotopic conditions (dim light conditions). This chart is a fast, easy, and effective way to measure spatial contrast sensitivity with reliable and reproducible results(60). This study will therefore help clinicians gain more insight into glaucoma related disability and provide a possible additional tool to visual field testing in patients with advanced glaucoma where VF testing may be hampered by floor effects.
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| Measure | Description | Time Frame |
|---|---|---|
| vision-related quality of life in patients with glaucoma | assessed using the the visual functioning questionnaire - 25 questionnaire | 1 day study visit |
| Visual function | assessed using the low luminance questionnaire | through study completion, an average of 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| To correlate visual impairment with contrast sensitivity results | measured with Quality of Life questionnaires (Visual Functioning Questionnaire-25, Low Luminance Questionnaire) | through study completion, an average of 1 year |
| Contrast Sensitivitiy |
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Inclusion Criteria:
• Male or Female, aged 40 years or above.
Exclusion Criteria:
• Neovascular, uveitic, acute angle closure glaucoma
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Patients with a diagnosis of glaucoma (including primary open angle glaucoma, pigment dispersion syndrome, pseudoexfoliation, normal tension glaucoma, chronic angle closure glaucoma, narrow angle glaucoma) or ocular hypertension aged ≥40 years old.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Portsmouth Hospitals NHS Trust | Portsmouth | Hampshire | PO6 3LY | United Kingdom |
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| ID | Term |
|---|---|
| D005901 | Glaucoma |
| ID | Term |
|---|---|
| D009798 | Ocular Hypertension |
| D005128 | Eye Diseases |
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Participants' contrast sensitivity will be tested under photopic (bright light conditions), mesopic (intermediate light conditions) and/or scotopic conditions (dim light conditions).
| through study completion, an average of 1 year |