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In this study, we aimed to investigate the relationship between PTEN-AKT-FOXO3 gene expression and decrease in ovarian reserve in the presence of endometrioma and other benign ovarian pathologies.
It is known that the presence of endometrioma negatively affects ovarian reserve. The development of endometriosis and the effect of the presence of endometrioma on ovarian reserve due to decreased PTEN expression are considered. This study was designed to compare ovarian PTEN-AKT-FOXO3 gene expression and ovarian reserve in patients with underwent surgery caused by endometrioma and those who had ovarian pathology due to other benign causes and PTEN-AKT-FOXO3 gene expression level will be evaluated by RT-PCR analysis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PATİENCE GROUP |
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| PATİENCE-CONTROL GROUP |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PTEN-AKT-FOXO3 Gene Expression | Genetic | In the patient and patient control groups, 0.5 mm tissue strip will be removed for pathology from the cyst wall removed during surgery. and tissue samples will be stored in phosphate buffered saline at -80 C and PTEN-AKT-FOXO3 gene expression level will be evaluated by RT-PCR analysis. |
| Measure | Description | Time Frame |
|---|---|---|
| PTEN AKT FOXO3 gene expression | In the patient and patient control groups, 0.5 mm tissue strip will be removed for pathology from the cyst wall removed during surgery. and tissue samples will be stored in phosphate buffered saline at -80 C and PTEN-AKT-FOXO3 gene expression level will be evaluated by RT-PCR analysis. | 30 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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The study population is the patients examined for ovarian endometriomas and other benign ovarian pathologies
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| HAMZA F SEN, MD | Contact | +90 544 3939159 | hamzafurkansen@yahoo.com | |
| Isil Kasapoglu, MD | Contact | +905305455848 | kasapogluisil@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| GURKAN UNCU, Prof | ULUDAG UNIVERSITY HOSPITAL BURSA TURKEY | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Uludag University Hospital, Department of Obstetrics and Gynecology | Recruiting | Bursa | Nilufer | 16059 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24154570 | Background | Govatati S, Kodati VL, Deenadayal M, Chakravarty B, Shivaji S, Bhanoori M. Mutations in the PTEN tumor gene and risk of endometriosis: a case-control study. Hum Reprod. 2014 Feb;29(2):324-36. doi: 10.1093/humrep/det387. Epub 2013 Oct 23. | |
| 29935810 | Background | Kasapoglu I, Ata B, Uyaniklar O, Seyhan A, Orhan A, Yildiz Oguz S, Uncu G. Endometrioma-related reduction in ovarian reserve (ERROR): a prospective longitudinal study. Fertil Steril. 2018 Jul 1;110(1):122-127. doi: 10.1016/j.fertnstert.2018.03.015. Epub 2018 Jun 20. |
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| ID | Term |
|---|---|
| D004715 | Endometriosis |
| ID | Term |
|---|---|
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| Uludag University Hospital, Department of Obstetrics and Gynecology | Recruiting | Bursa | Nilufer | 16059 | Turkey (Türkiye) |
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| D000091662 | Genital Diseases |