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This study aimed to measure the effects of SIH and DH on the mortality outcomes of the adult patients with moderate to severe thoracoabdominal injury
Because the pathophysiologic response of the patients with a thoracoabdominal injury is different from those who had a traumatic brain injury, this study aimed to measure the effects of hyperglycemia induced by stress or by diabetes on the outcomes of patients with thoracoabdominal injuries in comparison with those who had non-diabetic normoglycemia (NDN). The primary study hypothesis stated that, following thoracoabdominal injuries, the patients with SIH had a worse outcome than patients with DH. The primary outcome was mortality rate of these patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| adult patients with thoracoabdominal injuries | adult patients with moderate to severe thoracoabdominal injuries |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Stress-induced hyperglycemia | Other | Stress-induced hyperglycemia (SIH)was defined as a serum glucose ≥ 200 mg/dL in the patients without Diabetes mellitus. |
|
| Measure | Description | Time Frame |
|---|---|---|
| in-hospital mortality | The primary outcome of the study was in-hospital mortality. | up to 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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This retrospective study reviewed data from trauma patients registered between January 1, 2009 and December 31, 2018. The inclusion criteria were age ≥20 years Adult patients with moderate to severe thoracoabdominal injuries (n = 802) were grouped into four exclusive subgroups: (1) SIH, which was defined as a serum glucose ≥ 200 mg/dL in the patients without DM (n = 52); (2) DH, which indicated a serum glucose ≥ 200 mg/dL in patients with DM (n = 79); (3), DN, which was defined when there was a serum glucose < 200 mg/dL in the patients with DM (n = 50); and (4) NDN, indicating a serum glucose < 200 mg/dL in patients who were absent of DM (n = 621)
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| Name | Affiliation | Role |
|---|---|---|
| TSANG-TANG Hsieh | Chang Gung Memorial Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kaohsiung Chang Gung Memorial Hospital | Kaohsiung City | 83301 | Taiwan |
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| Diabetic hyperglycemia | Other | Diabetic hyperglycemia (DH) which indicated a serum glucose ≥ 200 mg/dL in patients with Diabetes mellitus. |
|
| Diabetic normoglycemia | Other | Diabetic normoglycemia (DN), which was defined when there was a serum glucose < 200 mg/dL in the patients with Diabetes mellitus. |
|
| Non-diabetic normoglycemia | Other | Non-diabetic normoglycemia (NDN) indicating a serum glucose < 200 mg/dL in patients who were absent of Diabetes mellitus. |
|
| ID | Term |
|---|---|
| D000007 | Abdominal Injuries |
| D013898 | Thoracic Injuries |
| D006943 | Hyperglycemia |
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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