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| Name | Class |
|---|---|
| Turkish Neonatology Society | OTHER |
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Stem cell therapies have been promising therapies in neonatal morbidities such as bronchopulmonary dysplasia, intraventricular hemorrhage and hypoxic ischemic encephalopathy. Although researchers showed those effects by several mechanisms including paracrine effect, regenerative and restorative effects, there is no obvious recommendations for the type of stem cells, dosage or the route of administration the cells. The usage of exogenous stem cells can be difficult due to technical issues in preterm infants.
In the presence of these data, the amount of endogenous stem cells passing through the cord to the infant may show differences in terms of delayed cord clamping and milking. Therefore the aim of this prospective randomized study is to determine the quantity of the stem cells according to delayed cord clamping or cord milking. We also aimed to evaluate the association between the number of stem cells and neonatal morbidities.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Delayed Cord Clamping for 30 seconds | Experimental | Infants whose umbilical cord clamping will be delayed for 30 secs. |
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| Delayed Cord Clamping for 60 seconds | Experimental | Infants whose umbilical cord clamping will be delayed for 60 secs. |
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| Umbilical Cord Milking | Experimental | Infants whose umbilical cord will be clamped after milking from the distance of 20 cm from mother's side to the baby for 3-4 times. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Delayed umbilical cord clamping | Procedure | During the C section, infants' umbilical cord clamping will be delayed for 30-60 seconds. |
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| Measure | Description | Time Frame |
|---|---|---|
| Concentration of Stem cells | Determining the quantity of endogenous stem cells transmitted through the umbilical cord to the infant after different types of cord clamping. | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Participants with Neonatal Morbidities | Recording newborn morbidities such as intraventricular hemorrhage , necrotizing enterocolitis, bronchopulmonary dysplasia , retinopathy of prematurity which are detected in the study population. | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Seda Yilmaz Semerci | Contact | 05337180683 | sedayilmazsemerci@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Seda Yilmaz Semerci | Kanuni Sultan Süleyman Eah | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Istanbul Kanuni Sultan Suleyman Training and Research Hospital | Recruiting | Istanbul | 34303 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D000087526 | Umbilical Cord Clamping |
| ID | Term |
|---|---|
| D036861 | Delivery, Obstetric |
| D013513 | Obstetric Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
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| Cord Milking | Procedure | Umbilical cord will be milked from th distance of 20cm from mother's side to the baby, for 3-4 times. |
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