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The aim of this study was to evaluate the efficacy and safety of topical application of tacrolimus at different concentrations for superficial Kaposiform hemangioendothelioma (KHE) and tufted angioma (TA).
Kaposiform hemangioendothelioma (KHE) and tufted angiomas (TA) are rare vascular tumors, which are apparent predominantly in infancy or early childhood. Currently, no standard treatment regimens exist for KHE/TA. The aim of this study was to evaluate the efficacy and safety of topical application of tacrolimus at different concentrations for superficial Kaposiform hemangioendothelioma (KHE) and tufted angioma (TA).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patients treated with tacrolimus 0.03% ointment | Experimental | patients treated with tacrolimus 0.03% ointment |
|
| patients treated with tacrolimus 0.1% ointment | Active Comparator | patients treated with tacrolimus 0.1% ointment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tacrolimus ointment | Drug | topical application of tacrolimus at different concentrations for treatment of superficial Kaposiform hemangioendothelioma (KHE) and tufted angioma (TA). |
| Measure | Description | Time Frame |
|---|---|---|
| reduction in the size of the lesion | Therapeutic effect is evaluated by reduction in the size of the tumor measured by centimeters. | 2.5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Rate of Adverse events | using the measurement of ratio to evaluate the rate of adverse events of topical application of tacrolimus (such as ratio of Acne vulgaris, pruritis and rash etc.). | 2.5 years |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yi Ji, PHD, MD | Contact | +86 13980544622 | jijiyuanyuan@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Yi Ji | West China Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| West China Hospital of Sichuan University | Recruiting | Chengdu | Sichuan | 610041 | China |
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| ID | Term |
|---|---|
| C537007 | Kaposiform Hemangioendothelioma |
| C536924 | Tufted angioma |
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