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PTSD is characterized by physiological changes, some of which are thought to be chronic, while others are observed in response to stressogenic stimuli. Prolonged Exposure (PE) therapy is a widely used protocol considered highly affective among individuals diagnosed with PTSD.
The current study is a non-interventional observational study, aimed at measuring changes in the digital phenotype of participants with PTSD during and following PE therapy. Physiological data will be collected using wearable sensors during the sessions, and participants will be assessed using questionnaires and psychiatric assessments before and after the completion of their imaginal or writing based PE therapy (10-15 sessions).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Imaginal PE | |||
| Writing PE |
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| Measure | Description | Time Frame |
|---|---|---|
| Changes in Heart Rate | Heart Rate and HRV (Heart Rate Variability) | 3 months |
| Changes in Saturation | Changes in saturation SPO2 (oxygen saturation by pulse oximetry) | 3 months |
| Changes in blood pressure | Changes in Continuous Blood Pressure | 3 months |
| Changes in Pulse Pressure | Changes in Pulse Pressure | 3 months |
| Changes in Respiratory rate | Changes in Respiratory rate | 3 months |
| Changes in Stroke Volume | Changes in Stroke Volume | 3 months |
| Changes in Systemic Vascular Resistance | Changes in Systemic Vascular Resistance | 3 months |
| Changes in sweat | Changes in Sweat | 3 months |
| Changes in Body Temperature | Changes in Body Temperature |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between changes in digital phenotype (multiple measures) | Correlation between changes in digital phenotype during the sessions and the clinical improvement according to the psychiatric evaluation and questionnaires. | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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Adult (aged 18 and over) participants diagnosed with PTSD and undergoing PE therapy; 50 using imaginal PE and 50 using writing PE.
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| ID | Term |
|---|---|
| D013313 | Stress Disorders, Post-Traumatic |
| ID | Term |
|---|---|
| D040921 | Stress Disorders, Traumatic |
| D000068099 | Trauma and Stressor Related Disorders |
| D001523 | Mental Disorders |
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| 3 months |
| Changes in Cardiac Output | Changes in Cardiac Output | 3 months |