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The purpose of this study is to determine, among a large cohort of 300 consecutive patients with hypertrophic cardiomyopathy, if extended ambulatory monitoring using the iRhythm Technologies, Inc. Zio XT device results in identifying a greater burden of nonsustained ventricular tachyarrhythmia (nsVT) compared to current ACCF/AHA guideline recommended 48-hour monitoring.
Optimal duration to monitor patients for identifying nsVT remains unclear. The investigators aim to determine the prevalence and burden of nsVT with longer term monitoring with the iRhythm Zio XT device over a 2-week period vs. 48 hours; and whether, this greater burden of nsVT compared to conventional shorter monitoring potentially identifies a subset of HCM patients who may be at higher risk of sudden cardiac death.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HCM Group | Eligible HCM subjects will be monitored for arrhythmias with a 2-week ECG patch. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Zio XT | Device | ambulatory cardiac monitoring device |
|
| Measure | Description | Time Frame |
|---|---|---|
| Total number of nsVT runs through 14 days of ambulatory cardiac monitoring, as compared to the first 48 hours. | Compare the number of nsVT runs detected between the first 48 hours vs 2 weeks of ambulatory cardiac monitoring. | 14 days |
| Measure | Description | Time Frame |
|---|---|---|
| Total number of atrial fibrillation runs through 14 days of ambulatory cardiac monitoring, as compared to the first 48 hours. | Compare the number of AF runs detected between the first 48 hours vs 2 weeks of ambulatory cardiac monitoring. | 14 days |
| Number of clinical management decisions based on 14 days of ambulatory cardiac monitoring, as compared to the first 48 hours ambulatory cardiac monitoring. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients from the hypertrophic cardiomyopathy population will be recruited.
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| Name | Affiliation | Role |
|---|---|---|
| Martin Maron, MD | Tufts Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tufts Medical Center | Boston | Massachusetts | 02111 | United States |
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| ID | Term |
|---|---|
| D002312 | Cardiomyopathy, Hypertrophic |
| D017180 | Tachycardia, Ventricular |
| D001281 | Atrial Fibrillation |
| D001145 | Arrhythmias, Cardiac |
| ID | Term |
|---|---|
| D009202 | Cardiomyopathies |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D001020 | Aortic Stenosis, Subvalvular |
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Compare the number clinical decisions based on the first 48 hours vs 14 days of ambulatory cardiac monitoring. |
| 14 days |
| D001024 |
| Aortic Valve Stenosis |
| D000082862 | Aortic Valve Disease |
| D006349 | Heart Valve Diseases |
| D013610 | Tachycardia |
| D000075224 | Cardiac Conduction System Disease |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |