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| Name | Class |
|---|---|
| Zhejiang University Interdisciplinary Institute of Neuroscience and Technology | UNKNOWN |
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To discover the microstructure, macrostructure and functional changes with 7T multi-modal magnetic resonance imaging of Neuronal Intranuclear Inclusion Disease, and to explore new biomarkers for evaluating the severity and the progression of Neuronal Intranuclear Inclusion Disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| NIID | NIID patients | ||
| HC | healthy control |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Other | There is no Intervention. |
|
| Measure | Description | Time Frame |
|---|---|---|
| fractional anisotropy (FA) | Parameters to describe integrity of white matter in diffusion MR Imaging | baseline |
| mean diffusivity (MD) | Parameters to describe integrity of white matter in diffusion MR Imaging | baseline |
| Intracellular volume fraction(icvf) | Parameters to describe integrity of white matter in diffusion MR Imaging | baseline |
| orientation dispersion index (ODI) | Parameters to describe integrity of white matter in diffusion MR Imaging | baseline |
| fiber number(fiber pass through the lesions) | Parameters to describe integrity of white matter in diffusion MR Imaging | baseline |
| fractional anisotropy (FA) | Parameters to describe integrity of white matter in diffusion MR Imaging | 6 months |
| mean diffusivity (MD) | Parameters to describe integrity of white matter in diffusion MR Imaging | 6 months |
| Intracellular volume fraction(icvf) | Parameters to describe integrity of white matter in diffusion MR Imaging |
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Inclusion Criteria:
Exclusion Criteria:
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Subjects enrolled in the study shall be selected from NIID patients who are diagnosed with skin biopsy and gene detection. The Investigator is responsible for screening potential subjects and selecting those who meet the eligibility criteria for the study as described.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hui Liang, Doctor | Contact | 18757139736 | +86 | pushup@zju.edu.cn |
| Daqiang Ke, Bachelor | Contact | 15658173819 | +86 | zhemuzhi@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Ruiliang Bai, Doctor | Zhejiang University Interdisciplinary Institute of Neuroscience and Technology (ZIINT) | Principal Investigator |
| Hui Liang, Doctor | Zhejiang University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Siemens 7T MR | Recruiting | Hangzhou | Zhejiang | 310003 | China |
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| ID | Term |
|---|---|
| C537395 | Neuronal intranuclear inclusion disease |
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| 6 months |
| orientation dispersion index (ODI) | Parameters to describe integrity of white matter in diffusion MR Imaging | 6 months |
| fiber number(fiber pass through the lesions) | Parameters to describe integrity of white matter in diffusion MR Imaging | 6 months |
| short-range and long-range functional connectivity around the lesions at rest | Functional network connectivity impairments in patients | baseline |
| short-range and long-range functional connectivity around the lesions at rest | Functional network connectivity impairments in patients | 6 months |