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The aim of the current study, therefore, is to determine the feasibility of recruitment and adherence to resistance exercise training interventions performed at low and high loads, to volitional muscular failure, in a trial population that includes both healthy and frail older people.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Low load | Experimental | Training at 30-40% one-repetition maximum (1RM) |
|
| High load | Experimental | Training at 65-75% one-repetition maximum (1RM) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Low Load Resistance exercise | Behavioral | leg extension, leg press, leg curl and calf press |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Muscle strength | Knee extensor maximal torque during an isometric MVC | Change from baseline to 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Vastus lateralis muscle thickness | Measured via ultrasound | Change from baseline to 8 weeks |
| Muscle strength | Knee flexor maximal torque during an isometric MVC |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stuart Gray | University of Glasgow | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| GRI Clinical Research Facility | Glasgow | G12 8TA | United Kingdom |
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| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| D000073496 | Frailty |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| High Load Resistance exercise |
| Behavioral |
leg extension, leg press, leg curl and calf press |
|
| Change from baseline to 8 weeks |
| One-repetition maximum | leg extension, leg curl, leg press and calf press | Change from baseline to 8 weeks |
| Biomechanics during walking and stair climbing | Motion analysis | Change from baseline to 8 weeks |
| Short performance physical battery test | SPPB - balance, walking pace and chair rise | Change from baseline to 8 weeks |
| Quality of life measure | EQ-5D-5L questionnaire | Change from baseline to 8 weeks |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D010335 | Pathologic Processes |