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Low Enrollment
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| Name | Class |
|---|---|
| GBS-CIDP foundation | UNKNOWN |
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The purpose of this study is to determine if peripheral nerve ultrasound can be used as a supplemental tool to diagnose Guillain-Barre syndrome (GBS) in the acute setting and aid in prognostication.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| GBS Patients | Experimental |
| |
| Controls | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Peripheral nerve ultrasound | Diagnostic Test | Ultrasound of the bilateral ulnar nerves, median nerves, vagus nerves, and C6 and C7 nerve roots will be performed. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Internerve Variability of Cross-sectional Area (CSA) in Patients With GBS vs Controls | Internerve CSA variability for each patient will be calculated as: maximal intranerve CSA variability/minimal intranerve CSA variability. Intranerve CSA variability for each nerve will be calculated as: maximal CSA/minimal CSA for median and ulnar nerves. | Day 0 and approximately 7 days after admission |
| Median Nerve Intranerve Cross-sectional Area (CSA) Variability in Patients With GBS vs Controls | Intranerve CSA variability for each nerve is calculated as: maximal intranerve CSA/minimal intranerve CSA . When both left and right ulnar nerves were scanned, the side with the largest intranerve CSA variability was used for analysis. | Day 0 and approximately 7 days after admission |
| Ulnar Nerve Intranerve Cross-sectional Area (CSA) Variability in Patients With GBS vs Controls | Intranerve CSA variability for each nerve is calculated as: maximal intranerve CSA/minimal intranerve CSA . When both left and right ulnar nerves were scanned, the side with the largest intranerve CSA variability was used for analysis. | Day 0 and approximately 7 days after admission |
| Measure | Description | Time Frame |
|---|---|---|
| Length of Hospital Stay in Days | Length of hospital stay is measured to the nearest day (by chart review). | Up to approximately 20 days |
| Ambulatory Status on Discharge | Number of participants with ambulatory status as "ambulatory with or without assistance". |
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Inclusion Criteria:
Exclusion Criteria:
- Patients with any history of multifocal motor neuropathy (MMN), prior Guillain-Barre syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), or hereditary neuropathy (e.g. Charcot-Marie-Tooth)
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| Name | Affiliation | Role |
|---|---|---|
| Lisa Hobson-Webb, M.D. | Duke University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Duke University Hospital | Durham | North Carolina | 27710 | United States |
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| ID | Title | Description |
|---|---|---|
| FG000 | GBS Patients | Peripheral nerve ultrasound: Ultrasound of the bilateral ulnar nerves, median nerves, vagus nerves, and C6 and C7 nerve roots will be performed. Measurement of strength: Strength will be assessed by physical examination and recorded using Medical Research Council (MRC) scale, and a hand dynamometer will be used to measure grip strength. |
| FG001 | Controls | Peripheral nerve ultrasound: Ultrasound of the bilateral ulnar nerves, median nerves, vagus nerves, and C6 and C7 nerve roots will be performed. |
| Title | Milestones | Reasons Not Completed | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
|
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| ID | Title | Description |
|---|---|---|
| BG000 | GBS Patients | Peripheral nerve ultrasound: Ultrasound of the bilateral ulnar nerves, median nerves, vagus nerves, and C6 and C7 nerve roots will be performed. Measurement of strength: Strength will be assessed by physical examination and recorded using Medical Research Council (MRC) scale, and a hand dynamometer will be used to measure grip strength. |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Internerve Variability of Cross-sectional Area (CSA) in Patients With GBS vs Controls | Internerve CSA variability for each patient will be calculated as: maximal intranerve CSA variability/minimal intranerve CSA variability. Intranerve CSA variability for each nerve will be calculated as: maximal CSA/minimal CSA for median and ulnar nerves. | Participants with data collected at each time point. | Posted | Mean | Standard Deviation | mm^2 | Day 0 and approximately 7 days after admission |
|
Adverse Events were not collected.
Adverse Events were not collected.
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | GBS Patients | Peripheral nerve ultrasound: Ultrasound of the bilateral ulnar nerves, median nerves, vagus nerves, and C6 and C7 nerve roots will be performed. Measurement of strength: Strength will be assessed by physical examination and recorded using Medical Research Council (MRC) scale, and a hand dynamometer will be used to measure grip strength. |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Natalia Gonzalez, MD | Duke University | 919-684-5422 | natalia.gonzalez@duke.edu |
| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Sep 10, 2021 | Apr 24, 2025 | Prot_001.pdf |
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| ID | Term |
|---|---|
| D020275 | Guillain-Barre Syndrome |
| ID | Term |
|---|---|
| D011129 | Polyradiculoneuropathy |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
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The EMG lab physician or technician performing the ultrasound will be blinded to the EMG/NCS results.
| Measurement of strength | Diagnostic Test | Strength will be assessed by physical examination and recorded using Medical Research Council (MRC) scale, and a hand dynamometer will be used to measure grip strength. |
|
| At discharge, up to approximately 20 days |
| Respiratory Dysfunction, as Measured by Number of Days Intubated | Respiratory dysfunction will be measured by number of days intubated (to the nearest day) by chart review. | During admission, up to approximately 20 days |
| Strength, as Measured by Hand Dynamometer | Average of left and right hand grip strength (in pounds). | Day 0, Day 7 |
| Strength, as Measured by Medical Research Council (MRC) | The Medical Research Council (MRC) total score ranges from 0-60, with higher values indicating greater muscle strength. The MRC total score is the sum score of the following muscle group subscales (each assessed on the left side and right side): bilateral shoulder abduction, elbow flexion, wrist extension, hip flexion, knee extension, and ankle dorsiflexion. Each muscle group subscale is rated 0-5, with 0 being no movement and 5 being full strength. | Day 0, Day 7 |
| Number of Participants With Autonomic Dysfunction | Autonomic dysfunction will be either present or absent by chart review during hospitalization. | During hospitalization, up to approximately 20 days |
| Disability as Measured by the Guillain-Barre Syndrome (GBS) Disability Score | The GBS disability score ranges from 0-6 with lower scores indicating a better outcome (0 is healthy, 6 is death). | Day 0, Day 7, Discharge (up to approximately 20 days), Day 90, Day 180 |
| BG001 |
| Controls |
Peripheral nerve ultrasound: Ultrasound of the bilateral ulnar nerves, median nerves, vagus nerves, and C6 and C7 nerve roots will be performed. |
| BG002 | Total | Total of all reporting groups |
| years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Ethnicity (NIH/OMB) | Count of Participants | Participants |
|
| Race (NIH/OMB) | Count of Participants | Participants |
|
| Region of Enrollment | Count of Participants | Participants |
|
| OG001 | Controls | Peripheral nerve ultrasound: Ultrasound of the bilateral ulnar nerves, median nerves, vagus nerves, and C6 and C7 nerve roots will be performed. |
|
|
|
| Primary | Median Nerve Intranerve Cross-sectional Area (CSA) Variability in Patients With GBS vs Controls | Intranerve CSA variability for each nerve is calculated as: maximal intranerve CSA/minimal intranerve CSA . When both left and right ulnar nerves were scanned, the side with the largest intranerve CSA variability was used for analysis. | Participants with data collected at each time point. | Posted | Mean | Standard Deviation | mm^2 | Day 0 and approximately 7 days after admission |
|
|
|
|
| Primary | Ulnar Nerve Intranerve Cross-sectional Area (CSA) Variability in Patients With GBS vs Controls | Intranerve CSA variability for each nerve is calculated as: maximal intranerve CSA/minimal intranerve CSA . When both left and right ulnar nerves were scanned, the side with the largest intranerve CSA variability was used for analysis. | Participants with data collected at each time point. | Posted | Mean | Standard Deviation | mm^2 | Day 0 and approximately 7 days after admission |
|
|
|
|
| Secondary | Length of Hospital Stay in Days | Length of hospital stay is measured to the nearest day (by chart review). | Not applicable to the Control group. | Posted | Mean | Standard Deviation | days | Up to approximately 20 days |
|
|
|
|
| Secondary | Ambulatory Status on Discharge | Number of participants with ambulatory status as "ambulatory with or without assistance". | Not applicable to the Control group. | Posted | Count of Participants | Participants | At discharge, up to approximately 20 days |
|
|
|
|
| Secondary | Respiratory Dysfunction, as Measured by Number of Days Intubated | Respiratory dysfunction will be measured by number of days intubated (to the nearest day) by chart review. | Not applicable to the Control group. | Posted | Mean | Standard Deviation | days | During admission, up to approximately 20 days |
|
|
|
|
| Secondary | Strength, as Measured by Hand Dynamometer | Average of left and right hand grip strength (in pounds). | Participants with data collected at each time point. Not applicable to the Control group. | Posted | Mean | Standard Deviation | lbs | Day 0, Day 7 |
|
|
|
|
| Secondary | Strength, as Measured by Medical Research Council (MRC) | The Medical Research Council (MRC) total score ranges from 0-60, with higher values indicating greater muscle strength. The MRC total score is the sum score of the following muscle group subscales (each assessed on the left side and right side): bilateral shoulder abduction, elbow flexion, wrist extension, hip flexion, knee extension, and ankle dorsiflexion. Each muscle group subscale is rated 0-5, with 0 being no movement and 5 being full strength. | Participants with data collected at each time point. Not applicable to the Control group. | Posted | Mean | Standard Deviation | score on a scale | Day 0, Day 7 |
|
|
|
|
| Secondary | Number of Participants With Autonomic Dysfunction | Autonomic dysfunction will be either present or absent by chart review during hospitalization. | Not applicable to the Control group. | Posted | Count of Participants | Participants | During hospitalization, up to approximately 20 days |
|
|
|
|
| Secondary | Disability as Measured by the Guillain-Barre Syndrome (GBS) Disability Score | The GBS disability score ranges from 0-6 with lower scores indicating a better outcome (0 is healthy, 6 is death). | Not applicable to the Control group. Only one participant had data collected at Day 7. | Posted | Mean | Standard Deviation | score on a scale | Day 0, Day 7, Discharge (up to approximately 20 days), Day 90, Day 180 |
|
|
|
|
| 0 |
| 0 |
| 0 |
| 0 |
| 0 |
| 0 |
| EG001 | Controls | Peripheral nerve ultrasound: Ultrasound of the bilateral ulnar nerves, median nerves, vagus nerves, and C6 and C7 nerve roots will be performed. | 0 | 0 | 0 | 0 | 0 | 0 |
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| D011115 | Polyneuropathies |
| D010523 | Peripheral Nervous System Diseases |
| D009468 | Neuromuscular Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D000094025 | Post-Infectious Disorders |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| Day 7 |
|
|
| Day 7 |
|
|
| Kendall's tau correlation coefficient |
| -0.1628 |
| 2-Sided |
| 95 |
| -0.6503 |
| 0.4222 |
| Other |
Median at forearm |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and length of hospital stay. | Kendall's tau correlation coefficient | -0.1850 | 2-Sided | 95 | -0.5490 | 0.1829 | Other | Median at cubital fossa |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and length of hospital stay. | Kendall's tau correlation coefficient | 0.0512 | 2-Sided | 95 | -0.3411 | 0.5017 | Other | Median at humerus |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and length of hospital stay. | Kendall's tau correlation coefficient | 0.0476 | 2-Sided | 95 | -0.4335 | 0.5592 | Other | Median at axilla |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and length of hospital stay. | Kendall's tau correlation coefficient | -0.1229 | 2-Sided | 95 | -0.5092 | 0.3040 | Other | Ulnar at wrist |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and length of hospital stay. | Kendall's tau correlation coefficient | 0.0603 | 2-Sided | 95 | -0.3057 | 0.4137 | Other | Ulnar at forearm |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and length of hospital stay. | Kendall's tau correlation coefficient | 0.1059 | 2-Sided | 95 | -0.4028 | 0.5700 | Other | Ulnar at cubital fossa |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and length of hospital stay. | Kendall's tau correlation coefficient | -0.1786 | 2-Sided | 95 | -0.6503 | 0.2838 | Other | Ulnar at humerus |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and length of hospital stay. | Kendall's tau correlation coefficient | -0.2396 | 2-Sided | 95 | -0.5714 | 0.1950 | Other | Ulnar at axilla |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and length of hospital stay. | Kendall's tau correlation coefficient | -0.0671 | 2-Sided | 95 | -0.4667 | 0.3336 | Other | C6 |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and length of hospital stay. | Kendall's tau correlation coefficient | -0.2134 | 2-Sided | 95 | -0.7018 | 0.3193 | Other | C7 |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and length of hospital stay. | Kendall's tau correlation coefficient | 0.0246 | 2-Sided | 95 | -0.3506 | 0.4596 | Other | Vagus |
Null hypothesis: Nerve ultrasound measurement has no effect on the log-odds of walking (i.e., nerve ultrasound measurements do not predict whether a subject is ambulatory at discharge).
| Regression, Logistic |
| 0.521 |
| Odds Ratio (OR) |
| 0.9315228 |
| 2-Sided |
| Other |
Median at forearm |
| Null hypothesis: Nerve ultrasound measurement has no effect on the log-odds of walking (i.e., nerve ultrasound measurements do not predict whether a subject is ambulatory at discharge). | Regression, Logistic | 0.245 | Odds Ratio (OR) | 0.7949528 | 2-Sided | Other | Median at cubital fossa |
| Null hypothesis: Nerve ultrasound measurement has no effect on the log-odds of walking (i.e., nerve ultrasound measurements do not predict whether a subject is ambulatory at discharge). | Regression, Logistic | 0.541 | Odds Ratio (OR) | 0.8603349 | 2-Sided | Other | Median at humerus |
| Null hypothesis: Nerve ultrasound measurement has no effect on the log-odds of walking (i.e., nerve ultrasound measurements do not predict whether a subject is ambulatory at discharge). | Regression, Logistic | 0.415 | Odds Ratio (OR) | 0.8767973 | 2-Sided | Other | Median at axilla |
| Null hypothesis: Nerve ultrasound measurement has no effect on the log-odds of walking (i.e., nerve ultrasound measurements do not predict whether a subject is ambulatory at discharge). | Regression, Logistic | 0.504 | Odds Ratio, log | 0.7613965 | 2-Sided | Other | Ulnar at wrist |
| Null hypothesis: Nerve ultrasound measurement has no effect on the log-odds of walking (i.e., nerve ultrasound measurements do not predict whether a subject is ambulatory at discharge). | Regression, Logistic | 0.393 | Odds Ratio (OR) | 0.8061505 | 2-Sided | Other | Ulnar at forearm |
| Null hypothesis: Nerve ultrasound measurement has no effect on the log-odds of walking (i.e., nerve ultrasound measurements do not predict whether a subject is ambulatory at discharge). | Regression, Logistic | 0.222 | Odds Ratio (OR) | 0.8336885 | 2-Sided | Other | Ulnar at cubital fossa |
| Null hypothesis: Nerve ultrasound measurement has no effect on the log-odds of walking (i.e., nerve ultrasound measurements do not predict whether a subject is ambulatory at discharge). | Regression, Logistic | 0.615 | Odds Ratio (OR) | 1.1214848 | 2-Sided | Other | Ulnar at humerus |
| Null hypothesis: Nerve ultrasound measurement has no effect on the log-odds of walking (i.e., nerve ultrasound measurements do not predict whether a subject is ambulatory at discharge). | Regression, Logistic | 0.926 | Odds Ratio (OR) | 0.9898411 | 2-Sided | Other | Ulnar at axilla |
| Null hypothesis: Nerve ultrasound measurement has no effect on the log-odds of walking (i.e., nerve ultrasound measurements do not predict whether a subject is ambulatory at discharge). | Regression, Logistic | 0.519 | Odds Ratio (OR) | 0.9402829 | 2-Sided | Other | C6 |
| Null hypothesis: Nerve ultrasound measurement has no effect on the log-odds of walking (i.e., nerve ultrasound measurements do not predict whether a subject is ambulatory at discharge). | Regression, Logistic | 0.379 | Odds Ratio (OR) | 0.9347906 | 2-Sided | Other | C7 |
| Null hypothesis: Nerve ultrasound measurement has no effect on the log-odds of walking (i.e., nerve ultrasound measurements do not predict whether a subject is ambulatory at discharge). | Regression, Logistic | 0.511 | Odds Ratio (OR) | 0.8968658 | 2-Sided | Other | Vagus |
| Kendall's tau correlation coefficient |
| -0.0359442 |
| 2-Sided |
| 95 |
| -0.5480 |
| 0.5248 |
| Other |
Median at forearm |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and respiratory dysfunction. | Kendall's tau correlation coefficient | 0.1429483 | 2-Sided | 95 | -0.1938 | 0.4763 | Other | Median at cubital fossa |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and respiratory dysfunction. | Kendall's tau correlation coefficient | -0.3955939 | 2-Sided | 95 | -0.6811 | -0.0874 | Other | Median at humerus |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and respiratory dysfunction. | Kendall's tau correlation coefficient | -0.3681051 | 2-Sided | 95 | -0.7032 | 0.1185 | Other | Median at axilla |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and respiratory dysfunction. | Kendall's tau correlation coefficient | -0.4938292 | 2-Sided | 95 | -0.7112 | -0.1978 | Other | Ulnar at wrist |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and respiratory dysfunction. | Kendall's tau correlation coefficient | 0.1304373 | 2-Sided | 95 | -0.2201 | 0.5014 | Other | Ulnar at forearm |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and respiratory dysfunction. | Kendall's tau correlation coefficient | 0.3273268 | 2-Sided | 95 | -0.0679 | 0.6612 | Other | Ulnar at cubital fossa |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and respiratory dysfunction. | Kendall's tau correlation coefficient | -0.0552157 | 2-Sided | 95 | -0.4213 | 0.3610 | Other | Ulnar at humerus |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and respiratory dysfunction. | Kendall's tau correlation coefficient | -0.1666667 | 2-Sided | 95 | -0.5389 | 0.2057 | Other | Ulnar at axilla |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and respiratory dysfunction. | Kendall's tau correlation coefficient | -0.3194892 | 2-Sided | 95 | -0.6539 | 0.2288 | Other | C6 |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and respiratory dysfunction. | Kendall's tau correlation coefficient | -0.4959498 | 2-Sided | 95 | -0.6860 | -0.2065 | Other | C7 |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and respiratory dysfunction. | Kendall's tau correlation coefficient | -0.3228883 | 2-Sided | 95 | -0.6487 | 0.0000 | Other | Vagus |
| Day 7 |
|
|
| Kendall's tau correlation coefficient |
| 0.1987845 |
| 2-Sided |
| 95 |
| -0.4377 |
| 0.8004 |
| Other |
Median at forearm |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and strength by hand dynamometer. | Kendall's tau correlation coefficient | -0.0789747 | 2-Sided | 95 | -0.5256 | 0.3778 | Other | Median at cubital fossa |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and strength by hand dynamometer. | Kendall's tau correlation coefficient | 0.1621509 | 2-Sided | 95 | -0.3591 | 0.5606 | Other | Median at humerus |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and strength by hand dynamometer. | Kendall's tau correlation coefficient | 0.1499412 | 2-Sided | 95 | -0.3901 | 0.6374 | Other | Median at axilla |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and strength by hand dynamometer. | Kendall's tau correlation coefficient | -0.0140441 | 2-Sided | 95 | -0.5773 | 0.5407 | Other | Ulnar at wrist |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and strength by hand dynamometer. | Kendall's tau correlation coefficient | 0.01383297 | 2-Sided | 95 | -0.5288 | 0.5485 | Other | Ulnar at forearm |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and strength by hand dynamometer. | Kendall's tau correlation coefficient | -0.2935683 | 2-Sided | 95 | -0.6968 | 0.2414 | Other | Ulnar at cubital fossa |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and strength by hand dynamometer. | Kendall's tau correlation coefficient | 0.1067521 | 2-Sided | 95 | -0.5204 | 0.6392 | Other | Ulnar at humerus |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and strength by hand dynamometer. | Kendall's tau correlation coefficient | 0.0549235 | 2-Sided | 95 | -0.4633 | 0.5594 | Other | Ulnar at axilla |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and strength by hand dynamometer. | Kendall's tau correlation coefficient | -0.2597622 | 2-Sided | 95 | -0.6816 | 0.1857 | Other | C6 |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and strength by hand dynamometer. | Kendall's tau correlation coefficient | -0.0129034 | 2-Sided | 95 | -0.4476 | 0.4025 | Other | C7 |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and strength by hand dynamometer. | Kendall's tau correlation coefficient | 0.02457737 | 2-Sided | 95 | -0.3506 | 0.4596 | Other | Vagus |
| Day 7 |
|
|
| Kendall's tau correlation coefficient |
| 0.1704986 |
| 2-Sided |
| 95 |
| -0.3950 |
| 0.6584 |
| Other |
Median at forearm |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and strength by MRC sum score. | Kendall's tau correlation coefficient | 0.09040847 | 2-Sided | 95 | -0.3821 | 0.5979 | Other | Median at cubital fossa |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and strength by MRC sum score. | Kendall's tau correlation coefficient | 0.02501955 | 2-Sided | 95 | -0.4158 | 0.4790 | Other | Median at humerus |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and strength by MRC sum score. | Kendall's tau correlation coefficient | -0.0349215 | 2-Sided | 95 | -0.5033 | 0.4430 | Other | Median at axilla |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and strength by MRC sum score. | Kendall's tau correlation coefficient | -0.0961 | 2-Sided | 95 | -0.5458 | 0.4037 | Other | Ulnar at wrist |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and strength by MRC sum score. | Kendall's tau correlation coefficient | -0.2239171 | 2-Sided | 95 | -0.6514 | 0.2935 | Other | Ulnar at forearm |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and strength by MRC sum score. | Kendall's tau correlation coefficient | -0.0805076 | 2-Sided | 95 | -0.5371 | 0.2974 | Other | Ulnar at cubital fossa |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and strength by MRC sum score. | Kendall's tau correlation coefficient | 0.2910126 | 2-Sided | 95 | -0.2791 | 0.7651 | Other | Ulnar at humerus |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and strength by MRC sum score. | Kendall's tau correlation coefficient | 0.02342428 | 2-Sided | 95 | -0.4531 | 0.5267 | Other | Ulnar at axilla |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and strength by MRC sum score. | Kendall's tau correlation coefficient | 0.06536087 | 2-Sided | 95 | -0.2786 | 0.4454 | Other | C6 |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and strength by MRC sum score. | Kendall's tau correlation coefficient | 0.2207792 | 2-Sided | 95 | -0.2459 | 0.6708 | Other | C7 |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and strength by MRC sum score. | Kendall's tau correlation coefficient | 0.14415 | 2-Sided | 95 | -0.2333 | 0.4899 | Other | Vagus |
Null hypothesis: Nerve ultrasound measurement has no effect on the log-odds of having autonomic dysfunction (i.e., higher ultrasound measurements do not predict whether a subject has autonomic dysfunction during their hospitalization). |
| Regression, Logistic |
| 0.548 |
| Odds Ratio (OR) |
| 0.9310743 |
| 2-Sided |
| Other |
Median at forearm |
| Null hypothesis: Nerve ultrasound measurement has no effect on the log-odds of having autonomic dysfunction (i.e., higher ultrasound measurements do not predict whether a subject has autonomic dysfunction during their hospitalization). | Regression, Logistic | 0.250 | Odds Ratio (OR) | 1.23944918 | 2-Sided | Other | Median at cubital fossa |
| Null hypothesis: Nerve ultrasound measurement has no effect on the log-odds of having autonomic dysfunction (i.e., higher ultrasound measurements do not predict whether a subject has autonomic dysfunction during their hospitalization). | Regression, Logistic | 0.874 | Odds Ratio (OR) | 0.9613236 | 2-Sided | Other | Median at humerus |
| Null hypothesis: Nerve ultrasound measurement has no effect on the log-odds of having autonomic dysfunction (i.e., higher ultrasound measurements do not predict whether a subject has autonomic dysfunction during their hospitalization). | Regression, Logistic | 0.698 | Odds Ratio (OR) | 0.9442314 | 2-Sided | 95 | Other | Median at axilla |
| Null hypothesis: Nerve ultrasound measurement has no effect on the log-odds of having autonomic dysfunction (i.e., higher ultrasound measurements do not predict whether a subject has autonomic dysfunction during their hospitalization). | Regression, Logistic | 0.665 | Odds Ratio (OR) | 1.193941 | 2-Sided | Other | Ulnar at wrist |
| Null hypothesis: Nerve ultrasound measurement has no effect on the log-odds of having autonomic dysfunction (i.e., higher ultrasound measurements do not predict whether a subject has autonomic dysfunction during their hospitalization). | Regression, Logistic | 0.820 | Odds Ratio (OR) | 1.0524489 | 2-Sided | Other | Ulnar at forearm |
| Null hypothesis: Nerve ultrasound measurement has no effect on the log-odds of having autonomic dysfunction (i.e., higher ultrasound measurements do not predict whether a subject has autonomic dysfunction during their hospitalization). | Regression, Logistic | 0.193 | Odds Ratio (OR) | 1.21669122 | 2-Sided | Other | Ulnar at cubital fossa |
| Null hypothesis: Nerve ultrasound measurement has no effect on the log-odds of having autonomic dysfunction (i.e., higher ultrasound measurements do not predict whether a subject has autonomic dysfunction during their hospitalization). | Regression, Logistic | 0.314 | Odds Ratio (OR) | 1.2994068 | 2-Sided | Other | Ulnar at humerus |
| Null hypothesis: Nerve ultrasound measurement has no effect on the log-odds of having autonomic dysfunction (i.e., higher ultrasound measurements do not predict whether a subject has autonomic dysfunction during their hospitalization). | Regression, Logistic | 0.405 | Odds Ratio (OR) | 1.1015629 | 2-Sided | Other | Ulnar at axilla |
| Null hypothesis: Nerve ultrasound measurement has no effect on the log-odds of having autonomic dysfunction (i.e., higher ultrasound measurements do not predict whether a subject has autonomic dysfunction during their hospitalization). | Regression, Logistic | 0.389 | Odds Ratio (OR) | 0.9140133 | 2-Sided | Other | C6 |
| Null hypothesis: Nerve ultrasound measurement has no effect on the log-odds of having autonomic dysfunction (i.e., higher ultrasound measurements do not predict whether a subject has autonomic dysfunction during their hospitalization). | Regression, Logistic | 0.139 | Odds Ratio (OR) | 0.7982946 | 2-Sided | Other | C7 |
| Null hypothesis: Nerve ultrasound measurement has no effect on the log-odds of having autonomic dysfunction (i.e., higher ultrasound measurements do not predict whether a subject has autonomic dysfunction during their hospitalization). | Regression, Logistic | 0.622 | Odds Ratio (OR) | 0.9330042 | 2-Sided | Other | Vagus |
| Day 7 |
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| Discharge |
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| Day 90 |
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| Day 180 |
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Null hypothesis: There is no correlation between nerve ultrasound measurements and GBS Disability score at 3 months after enrollment.
| Kendall's tau correlation coefficient |
| 0.02596308 |
| 2-Sided |
| 95 |
| -0.4859 |
| 0.5555 |
| Other |
Median at forearm, 3 months |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and GBS Disability score at 3 months after enrollment. | Kendall's tau correlation coefficient | 0.05162687 | 2-Sided | 95 | -0.3342 | 0.4170 | Other | Median at cubital fossa, 3 months |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and GBS Disability score at 3 months after enrollment. | Kendall's tau correlation coefficient | -0.1714461 | 2-Sided | 95 | -0.6473 | 0.2723 | Other | Median at humerus, 3 months |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and GBS Disability score at 3 months after enrollment. | Kendall's tau correlation coefficient | -0.0531775 | 2-Sided | 95 | -0.5830 | 0.4451 | Other | Median at axilla, 3 months |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and GBS Disability score at 3 months after enrollment. | Kendall's tau correlation coefficient | 0.1371924 | 2-Sided | 95 | -0.3592 | 0.6944 | Other | Ulnar at wrist, 3 months |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and GBS Disability score at 3 months after enrollment. | Kendall's tau correlation coefficient | -0.0134595 | 2-Sided | 95 | -0.5145 | 0.4627 | Other | Ulnar at forearm, 3 months |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and GBS Disability score at 3 months after enrollment. | Kendall's tau correlation coefficient | 0.01313517 | 2-Sided | 95 | -0.5056 | 0.4833 | Other | Ulnar at cubital fossa, 3 months |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and GBS Disability score at 3 months after enrollment. | Kendall's tau correlation coefficient | -0.1196495 | 2-Sided | 95 | -0.5876 | 0.3467 | Other | Ulnar at humerus, 3 months |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and GBS Disability score at 3 months after enrollment. | Kendall's tau correlation coefficient | 0.00 | 2-Sided | 95 | -0.3682 | 0.3885 | Other | Ulnar at axilla, 3 months |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and GBS Disability score at 3 months after enrollment. | Kendall's tau correlation coefficient | 0.1194695 | 2-Sided | 95 | -0.4220 | 0.6686 | Other | C6, 3 months |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and GBS Disability score at 3 months after enrollment. | Kendall's tau correlation coefficient | -0.0593456 | 2-Sided | 95 | -0.5651 | 0.4540 | Other | C7, 3 months |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and GBS Disability score at 3 months after enrollment. | Kendall's tau correlation coefficient | -0.1920694 | 2-Sided | 95 | -0.5490 | 0.238 | Other | Vagus, 3 months |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and GBS Disability score at 6 months after enrollment. | Kendall's tau correlation coefficient | 0.3150905 | 2-Sided | Other | Median at wrist, 6 months |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and GBS Disability score at 6 months after enrollment. | Kendall's tau correlation coefficient | 0.1203751 | 2-Sided | Other | Median at forearm, 6 months |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and GBS Disability score at 6 months after enrollment. | Kendall's tau correlation coefficient | 0.2526605 | 2-Sided | 95 | -0.1865 | 0.6430 | Other | Median at cubital fossa, 6 months |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and GBS Disability score at 6 months after enrollment. | Kendall's tau correlation coefficient | -0.0736010 | 2-Sided | 95 | -0.5806 | 0.4223 | Other | Median at humerus, 6 months |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and GBS Disability score at 6 months after enrollment. | Kendall's tau correlation coefficient | 0.01369735 | 2-Sided | 95 | -0.5619 | 0.5236 | Other | Median at axilla, 6 months |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and GBS Disability score at 6 months after enrollment. | Kendall's tau correlation coefficient | 0.2685663 | 2-Sided | 95 | -0.2488 | 0.7683 | Other | Ulnar at wrist, 6 months |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and GBS Disability score at 6 months after enrollment. | Kendall's tau correlation coefficient | 0.1802776 | 2-Sided | 95 | -0.2573 | 0.6027 | Other | Ulnar at forearm, 6 months |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and GBS Disability score at 6 months after enrollment. | Kendall's tau correlation coefficient | 0.2571327 | 2-Sided | 95 | -0.2595 | 0.6227 | Other | Ulnar at cubital fossa, 6 months |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and GBS Disability score at 6 months after enrollment. | Kendall's tau correlation coefficient | -0.0684867 | 2-Sided | 95 | -0.5757 | 0.3944 | Other | Ulnar at humerus, 6 months |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and GBS Disability score at 6 months after enrollment. | Kendall's tau correlation coefficient | 0.1929429 | 2-Sided | 95 | -0.1828 | 0.5550 | Other | Ulnar at axilla, 6 months |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and GBS Disability score at 6 months after enrollment. | Kendall's tau correlation coefficient | 0.1975146 | 2-Sided | 95 | -0.3557 | 0.7344 | Other | C6, 6 months |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and GBS Disability score at 6 months after enrollment. | Kendall's tau correlation coefficient | -0.0754722 | 2-Sided | 95 | -0.6150 | 0.5083 | Other | C7, 6 months |
| Null hypothesis: There is no correlation between nerve ultrasound measurements and GBS Disability score at 6 months after enrollment. | Kendall's tau correlation coefficient | -0.0706753 | 2-Sided | 95 | -0.5042 | 0.3963 | Other | Vagus, 6 months |