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| Name | Class |
|---|---|
| University of Exeter | OTHER |
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This is a single-center, randomized, placebo-controlled pilot study to evaluate the effects of high intensity interval training (HIIT) and daily administration of BasisTM for 3 weeks, in 18-35 year old males.
The study will consist of a screening visit, baseline visit, followed by treatment and HIIT phase (3 weeks) and a post-supplementation, follow-up visit (this will occur 48 h (or more) after the final HIIT session). Following the screening phase, subjects who meet entry criteria will be randomly assigned to 1 of 2 treatment groups: recommended dose of BasisTM (250 mg Nicotinamide Riboside and 50 mg Pterostilbene) per day or matching-placebo in a 1:1 ratio.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1X dose of NRPT | Active Comparator |
| |
| Placebo | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| NRPT | Dietary Supplement | Subjects randomly assigned to the active group will receive Nicotinamide Riboside and Pterostilbene (each capsule contains 125 mg NR and 25 mg PT, total daily dose is 2 capsules) for 3 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Mitochondrial function | Measured via high-resolution respirometry using the Oroboros Oxygraph | 3 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Exercise Capacity | To measure maximal endurance capacity measured via VO2max | 3 weeks |
| Muscle strength | To measure maximal voluntary contraction using a force transducer strength chair |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Timothy Etheridge, PhD | University of Exeter | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Exeter | Exeter | EX1 2LU | United Kingdom |
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| Placebo oral capsule | Dietary Supplement | Subjects randomly assigned to the Placebo group will receive placebo oral capsules for 3 weeks |
|
| 3 weeks |
| Muscle power | Determine the effects of HIIT with and without NRPT supplementation on muscle power producing capabilities measured by the 30 second Wingate test | 3 weeks |
| Mitochondrial proteins | To determine whether HIIT with NRPT supplementation improves mitochondrial function more so than HIIT alone, using Western blotting | 3 weeks |
| Body Mass | To determine the effects of HIIT with and without NRPT supplementation on body composition by measuring body mass using a bioelectrical impedance analysis scale | 3 weeks |
| Percent Body Fat | To determine the effects of HIIT with and without NRPT supplementation on body composition by measuring percent body fat using a bioelectrical impedance analysis scale | 3 weeks |
| Recovery via POMS | To determine the effects of HIIT with and without NRPT supplementation on recovery via profile of mood states (POMS) | 3 weeks |
| Recovery via RESTQ | To determine the effects of HIIT with and without NRPT supplementation on recovery via recovery stress (RESTQ) questionnaire | 3 weeks |
| Physical activity levels using FitBit | To characterize volunteer's habitual physical activity levels. | 3 weeks |
| Height | Measure height using a stadiometer, to characterize demographics of recruited volunteers the recruited volunteers | 3 weeks |
| Blood pressure | Measure blood pressure using Dinamap Pro monitor to characterize demographics of recruited volunteers the recruited volunteers | 3 weeks |