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To investigate whether pancreatic cancer is the cause of heterotopic ossification of abdominal incision.
Heterotopic ossification of abdominal incision (HOAI) has long been regarded as a rare complication after general surgery. However,according to our retrospective analysis. HOAI was more frequently observed in the malignancy group (33/121 cases, 27.3%) than in the non- malignancy group. Because of the many biases in the retrospective analysis, the result was not widely shared.
The purpose of this prospective study is to confirm that pancreatic cancer is the cause of heterotopic ossification of abdominal incisions. According to postoperative pathology, the patients were divided into two groups: pancreatic cancer group and benign diseases group.The researchers will observe whether patients develop heterotopic ossification of the abdominal incision one year after surgery to conclude.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PDAC Group | Radical operations were performed through central abdominal incisions. The postoperative pathology was pancreatic ductal adenocarcinoma. |
| |
| Benign Group | The abdominal midline incision was performed and the postoperative pathology was benign. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bone alkaline phosphatase | Diagnostic Test | Hematologic indicators reflecting ossification. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of HOAI | HOAI is determined by CT, whose CT number is similar to that of the same spine. | 12 months |
| Bone alkaline phosphatase | Preoperative tests were performed and every three months postoperatively | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of distant metastasis and local recurrence | Patients with pancreatic cancer were divided into HOAI and non-HOAI groups to determine whether there were differences in the incidence of distant metastasis and local recurrence between the two groups. | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Overall survival | Patients with pancreatic cancer were divided into HOAI and non-HOAI groups to determine whether there were differences between the OS of two groups. | 5 years |
Inclusion Criteria:
Exclusion Criteria:
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Chinese Han population
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jishu Wei, MD,PhD | Contact | 086-025-68136891 | weijishu@njmu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Yi Miao, Prof. | Pancreas Center, The First Affiliated Hospital of Nanjing Medical University | Principal Investigator |
| Junli Wu, MD,PHD | Pancreas Center, The First Affiliated Hospital of Nanjing Medical University |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The first affiliated hospital of Nanjing Medical University | Nanjing | Jiangsu | 210029 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25075838 | Background | Ghuman MS, Saggar K. Images in clinical medicine. Heterotopic ossification of a midline abdominal incision. N Engl J Med. 2014 Jul 31;371(5):464. doi: 10.1056/NEJMicm1312006. No abstract available. | |
| 19204446 | Background | Kim J, Kim Y, Jeong WK, Song SY, Cho OK. Heterotopic ossification developing in surgical incisions of the abdomen: analysis of its incidence and possible factors associated with its development. J Comput Assist Tomogr. 2008 Nov-Dec;32(6):872-6. doi: 10.1097/RCT.0b013e318159c617. |
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| ID | Term |
|---|---|
| D010190 | Pancreatic Neoplasms |
| D009999 | Ossification, Heterotopic |
| ID | Term |
|---|---|
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004701 | Endocrine Gland Neoplasms |
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The ossification patients were sequenced with informed consent . Promise to keep their personal information confidential.
| Abdominal CT scan | Radiation | Observe whether HOAI occurs. |
|
| Jishu Wei, MD,PHD | Pancreas Center, The First Affiliated Hospital of Nanjing Medical University | Principal Investigator |
| 20400341 | Background | Koolen PG, Schreinemacher MH, Peppelenbosch AG. Heterotopic ossifications in midline abdominal scars: a critical review of the literature. Eur J Vasc Endovasc Surg. 2010 Aug;40(2):155-9. doi: 10.1016/j.ejvs.2010.03.010. Epub 2010 Apr 18. |
| 27098323 | Background | Isaacson BM, Potter BK, Bloebaum RD, Epperson RT, Kawaguchi BS, Swanson TM, Pasquina PF. Link Between Clinical Predictors of Heterotopic Ossification and Histological Analysis in Combat-Injured Service Members. J Bone Joint Surg Am. 2016 Apr 20;98(8):647-57. doi: 10.2106/JBJS.15.00895. |
| 26643987 | Background | Citak M, Grasmucke D, Suero EM, Cruciger O, Meindl R, Schildhauer TA, Aach M. The roles of serum alkaline and bone alkaline phosphatase levels in predicting heterotopic ossification following spinal cord injury. Spinal Cord. 2016 May;54(5):368-70. doi: 10.1038/sc.2015.211. Epub 2015 Dec 8. |
| D004066 |
| Digestive System Diseases |
| D010182 | Pancreatic Diseases |
| D004700 | Endocrine System Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |