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Periodontitis is a widely prevalent disease worldwide that has serious public health consequences. Its prognosis includes tooth loss and edentulism, a condition that negatively affects chewing causing functional disability; and esthetics causing social impairment. Consequently, periodontitis may end up causing marked impairment of the quality of life of the affected patients, impairment of general health and increasing the dental care costs significantly.
Changes in the oral mucosa arise by primary products resulting from tissue breakdown due to gingivitis. It then triggers the host cells to produce proteinases that mediate loss of marginal periodontal ligaments, apical migration of the junctional epithelium and apical spread of bacterial biofilm.
Therefore, this research aims to identify the risk of smoking to both periodontitis and oral cancer, and the risk of periodontitis to oral cancer.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Smokers |
| ||
| non-Smokers |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| biopsy for oral cancer | Diagnostic Test | surgical biopsy is to be taken for diagnosis of oral cancer or premalignant lesions |
|
| Measure | Description | Time Frame |
|---|---|---|
| Periodontitis | arising of periodontitis or increase in the grade of an already existing case of periodontitis | the 10 years of the study |
| Measure | Description | Time Frame |
|---|---|---|
| Oral cancer | Arising of a lesion of oral cancer or a premalignant lesion | the 10 years of the study |
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Inclusion Criteria:
Exclusion Criteria:
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Adult individuals
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ayat Gamal-AbdelNaser | Contact | 01001874257 | ayat.gamal@dentistry.cu.edu.eg |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cairo University | Cairo | 11562 | Egypt |
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| ID | Term |
|---|---|
| D055113 | Chronic Periodontitis |
| D009062 | Mouth Neoplasms |
| ID | Term |
|---|---|
| D010518 | Periodontitis |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D001706 | Biopsy |
| ID | Term |
|---|---|
| D003581 | Cytodiagnosis |
| D003584 | Cytological Techniques |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
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biopsy of cases having oral lesions
| periodontal examination | Diagnostic Test | Periodontal clinical examination to all by periodontal charting |
|
| D002908 |
| Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006258 | Head and Neck Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D003933 | Diagnosis |
| D013048 | Specimen Handling |
| D003949 | Diagnostic Techniques, Surgical |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |