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To assess depth of demarcation line in transepithelial versus epithelium-off accelerated cross-linking in keratoconus patients
Anterior segment optical coherence tomography "OCT" will be performed to evaluate the corneal stroma for the presence of demarcation line 1 month postoperatively by an independent observer unware of purpose of study
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Transepithelial accelerated cross-linking | Active Comparator | Paracel is instilled 1 drop every 1.5 minutes for 4.5 minutes then vibex-xtra is instilled 4 drops at 5.5 minutes followed by 1 drop at 6.5 minutes for a total soak time of 11 minutes followed by ultraviolet-A" UVA" irradiation with intended irradiance of 45mW/cm2 for 2.4 minutes |
|
| Epithelium-off accelerated cross-linking | Active Comparator | Vibex-rapid is instilled every 2 minutes for 10 minutes followed by ultraviolet-A "UVA" irradiation of 30 mW/cm2 for 4 minutes |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| corneal cross-linking | Procedure | Riboflavin is instilled over cornea followed by Ultraviolet-A irradiation |
|
| Measure | Description | Time Frame |
|---|---|---|
| evaluation of depth of demarcation line | Anterior segment optical coherence tomography "AS-OCT" is used to measure depth of demarcation line | 1 month postoperative |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sarah Azzam, MD | Contact | +201227425601 | sarahazzam@ymail.com |
| Name | Affiliation | Role |
|---|---|---|
| Sarah Azzam, MD | Kasr El Aini Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kasr Al Ainy teaching hospital | Recruiting | Cairo | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31662893 | Derived | Salah Y, Omar K, Sherif A, Azzam S. Study of Demarcation Line Depth in Transepithelial versus Epithelium-Off Accelerated Cross-Linking (AXL) in Keratoconus. J Ophthalmol. 2019 Sep 26;2019:3904565. doi: 10.1155/2019/3904565. eCollection 2019. |
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| ID | Term |
|---|---|
| D000094504 | Corneal Cross-Linking |
| ID | Term |
|---|---|
| D010778 | Photochemotherapy |
| D003131 | Combined Modality Therapy |
| D013812 | Therapeutics |
| D004358 | Drug Therapy |
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| D010789 |
| Phototherapy |