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Salivary cortisol is used as a diagnostic analysis in the investigation of suspected Cushings' syndrome. This study evaluates if liqourice intake increases salivary cortisol in healthy individuals. Late night salivary cortisol and cortisone is analysed before, during and after 7 days of liqourice intake in three different doses.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| glycyrrhizic acid 1.5 mg/kg body weight | Active Comparator | Liqourice corresponding to 1.5 mg glycyrrhizic acid per kg body weight is taken in the evening during 7 days. |
|
| glycyrrhizic acid 3.0 mg/kg body weight | Active Comparator | Liqourice corresponding to 3.0 mg glycyrrhizic acid per kg body weight is taken in the evening during 7 days. |
|
| glycyrrhizic acid 6.0 mg/kg body weight | Active Comparator | Liqourice corresponding to 6.0 mg glycyrrhizic acid per kg body weight is taken in the evening during 7 days. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Liqourice | Dietary Supplement | Liqourice corresponding to 1.5, 3.0 or 6.0 mg glycyrrhizic acid per kg body weight is taken in the evening during 7 days. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Late night salivary cortisol | Significantly increased salivary cortisol 23:00 PM compared to baseline (i.e. before start of liqourice intake). | day 1 to day 7 during liqourice intake |
| Time to normalization of late night salivary cortisol | Time from liqourice intake is stopped until significant increase of late night salivary cortisol from baseline (i.e. assuming outcome 1 is significant increase) is no longer significant. | 1-28 days efter liqourice intake is stopped |
| Measure | Description | Time Frame |
|---|---|---|
| Morning salivary cortisol | Significantly increased salivary cortisol 08:00 AM compared to baseline (i.e. before start of liqourice intake). | day 1-2 during liqourice intake |
| Late night salivary cortisol/cortisone ratio |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Per Dahlqvist, MD, PhD | Contact | +46-907853390 | per.dahlqvist@umu.se | |
| Nils Bäcklund, MD | Contact | +46-907850000 | nils.backlund@umu.se |
| Name | Affiliation | Role |
|---|---|---|
| Per Dahlqvist, MD, PhD | Umeå University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Public Health and Clinical, Umeå University | Recruiting | Umeå | 901 85 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26156970 | Result | Nieman LK. Cushing's syndrome: update on signs, symptoms and biochemical screening. Eur J Endocrinol. 2015 Oct;173(4):M33-8. doi: 10.1530/EJE-15-0464. Epub 2015 Jul 8. | |
| 22890008 | Result | Perogamvros I, Ray DW, Trainer PJ. Regulation of cortisol bioavailability--effects on hormone measurement and action. Nat Rev Endocrinol. 2012 Dec;8(12):717-27. doi: 10.1038/nrendo.2012.134. Epub 2012 Aug 14. |
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| ID | Term |
|---|---|
| D003480 | Cushing Syndrome |
| ID | Term |
|---|---|
| D000308 | Adrenocortical Hyperfunction |
| D000307 | Adrenal Gland Diseases |
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D019695 | Glycyrrhizic Acid |
| ID | Term |
|---|---|
| D053978 | Pentacyclic Triterpenes |
| D014315 | Triterpenes |
| D013729 | Terpenes |
| D006838 | Hydrocarbons |
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Each group of 10 individuals uses liqourice for 7 days and late night salivary cortisol and cortisone is analysed before (baseline), during and after (washout) intake.
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|
Significantly increased salivary cortisol 23:00 PM compared to baseline (i.e. before start of liqourice intake).
| day 1 to day 7 during liqourice intake |
| Time to normalization of late night salivary cortisol/cortisone ratio | Time from liqourice intake is stopped until significant increase of late night salivary cortisol from baseline (i.e. assuming outcome 1 is significant increase) is no longer significant. | 1-28 days efter liqourice intake is stopped |
| 8504732 | Result | Whorwood CB, Sheppard MC, Stewart PM. Licorice inhibits 11 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid levels and potentiates glucocorticoid hormone action. Endocrinology. 1993 Jun;132(6):2287-92. doi: 10.1210/endo.132.6.8504732. |
| 19783236 | Result | Perogamvros I, Owen LJ, Newell-Price J, Ray DW, Trainer PJ, Keevil BG. Simultaneous measurement of cortisol and cortisone in human saliva using liquid chromatography-tandem mass spectrometry: application in basal and stimulated conditions. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Nov 1;877(29):3771-5. doi: 10.1016/j.jchromb.2009.09.014. Epub 2009 Sep 18. |
| D009930 |
| Organic Chemicals |