The Research of Metabolomics on COPD

The Correlation Research Between the Omega-3 and Omega-6 Inflammatory Metabolites and Stable COPD.

Targeted metabolomics research was conducted on patients with chronic obstructive pulmonary disease (COPD). The correlation analyst between inflammation-related metabolites and lung function was analyzed by explored the metabolic pathways of inflammation-related omega-6 and omega-3 and combining them with lung function.

Based on the global initiative for chronic obstructive pulmonary disease, the 80 confirmed stable COPD patients with mild-to-moderate were involved, 80 COPD patients with severe and very severe, and age, sex, all matching 40 cases without lung disease. The participants information was collected. Whole blood and pulmonary function were examined at three time points: admission, six months and one year, at the same time, targeted metabolomic analysis method are applied to detect serum metabolites, According to the access to assess the different severity of COPD in the stable period and the level of metabolites in different admission periods. After that, correlation analysis was conducted with pulmonary function indicators and other clinical indicators to observe the research value of inflammation-related metabolites in the development of COPD.

Inclusion Criteria:

• COPD diagnosis
• The age ranges from 40 to 80
• No other pulmonary diseases
• No immune-related diseases

Exclusion Criteria:

• Not consistent with COPD diagnosis
• Age is out of range
• Interstitial lung disease, asthma and other lung diseases
• Immune system diseases
• Lost to follow-up