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The aim of the trial is to investigate the possibilities of improving visual impairments with eye training exercises (eye-yoga) in a total of 40 patients with glaucoma who have not previously been treated within a similar training program. 20 patients will be instructed how to do eye yoga to be performed dails for 4 weeks (max 30 min/day). As a control group of 20 patients will be instructed to read for 30 min/day for 4 weeks.
The following outcome measures will be investigated: High Resolution Perimetry, Humphrey Perimetry, Visual Acuity Test, Contrast Sensitivity Test, Microsaccades measurements, Intraocular Pressure Measurement, Electroencephalogram (EEG), Blood Pressure and Pulse Measurement and Dynamic Vessel Analysis (DVA - the blood supply in the eye (especially vascular dysregulation) .
Furthermore, factors that could influence response variability and the effectiveness of treatment will be analysed: (i) the role of mental stress (or stress resilience) and (ii) the influence of personality traits and quality of life.
The study is intended to further validate this home training program (eye yoga) for the treatment of visual impairment in glaucoma.
The aim of eye yoga is to improve microsaccade impairments in patient with primary open angle glaucoma. We will study how this affects visual performance and the physiology of the eye and brain
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Eye Yoga group | Active Comparator | Eye yoga exercises |
|
| Reading Group | Placebo Comparator | Passive reading |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Eye yoga | Behavioral | Eye yoga exercises at home given by a trained instructor |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Visual field size determined by perimetry measurements | Changes of the visual field's size, evaluated by static perimetry and high resolution perimetry measurements | 4 weeks |
| Microsaccade measurements | Changes in the deviation of eye movements when visual targets are followed, using a computerized test | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Blood circulation in the eye | Changes of the diameter of blood vessels in the eye, measured by vessel analysis | 4 weeks |
| EEG connectivities | Changes in alpha power using EEG recording (128 channels) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Bernhard A Sabel, PhD | Contact | +491732540612 | bernhard.sabel@med.ovgu.de |
| Name | Affiliation | Role |
|---|---|---|
| Bernhard A Sabel, PhD | University of Magdeburg | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Inst. of Medical Psychology, Univ. of Magdeburg | Recruiting | Magdeburg | 39120 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30256277 | Background | Dada T, Mittal D, Mohanty K, Faiq MA, Bhat MA, Yadav RK, Sihota R, Sidhu T, Velpandian T, Kalaivani M, Pandey RM, Gao Y, Sabel BA, Dada R. Mindfulness Meditation Reduces Intraocular Pressure, Lowers Stress Biomarkers and Modulates Gene Expression in Glaucoma: A Randomized Controlled Trial. J Glaucoma. 2018 Dec;27(12):1061-1067. doi: 10.1097/IJG.0000000000001088. | |
| 30412515 |
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The results will be available without restriction
After the results are published, unlimited duration
Contact to the principal investigator
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| ID | Term |
|---|---|
| D005901 | Glaucoma |
| ID | Term |
|---|---|
| D009798 | Ocular Hypertension |
| D005128 | Eye Diseases |
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| Passive Reading |
| Behavioral |
Passive reading at home |
|
| 4 weeks |
| Institute of Medical Psychology | Recruiting | Magdeburg | 39120 | Germany |
|
| Sabel BA, Flammer J, Merabet LB. Residual vision activation and the brain-eye-vascular triad: Dysregulation, plasticity and restoration in low vision and blindness - a review. Restor Neurol Neurosci. 2018;36(6):767-791. doi: 10.3233/RNN-180880. |
| 36866155 | Derived | Zhou W, Sabel BA. Vascular dysregulation in glaucoma: retinal vasoconstriction and normal neurovascular coupling in altitudinal visual field defects. EPMA J. 2023 Feb 16;14(1):87-99. doi: 10.1007/s13167-023-00316-6. eCollection 2023 Mar. |