Minimally invasive non-surgical therapy (MINST) is a new approach towards regeneration of deep periodontal defects. Important part of MINST procedure, besides usage of magnification loupes and piezo-electric devices seems to be the usage of special mini-curettes, originally mini-five and after mini-five of Hu-Friedy. So far only descriptive data about the clinical effects of such procedure are available and comparative studies that would include other treatment alternatives are lacking. Therefore, the aim of our study is, on split-mouth model, to compare the number of diseased sites (defined by probing depth ˃ 4 mm and bleeding on probing) after conventional non-surgical therapy and MINST with the usage of special mini-curettes. In addition, new 3D parameters obtained from 3D optical scanning will be developed for evaluation of volume changes of soft tissues.

Inclusion Criteria:

• periodontitis Stage III, grade B/C
• at least 20 teeth
• at least 9 teeth (excluding molars) in the upper jaw
• without FPD, implants
• without occlusal trauma signs
• no pathology of endodontic origin
• without chronic systemic diseases
• no periodontal treatment in the last 6 months

Exclusion Criteria:

• poor oral hygiene (PI > 20% at evaluation)
• antibiotic treatment in the last 6 months or during the observation period
• pregnant women, lactation, serious chronic systemic diseases, medication with known influence on periodontium or wound healing

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