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| Name | Class |
|---|---|
| Swiss Multiple Sclerosis Society | UNKNOWN |
| Bangerter-Rhyner Stiftung | UNKNOWN |
| Center for Chronic Immunodeficiency (CCI) in Freiburg, Germany | UNKNOWN |
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This monocentric study is to identify factors that increase the susceptibility for infections and establish a questionnaire-based infection score that allows a prospective stratification for infectious risks in patients with multiple sclerosis (MS) (InRIMS-Study). The study will utilize a validated, MS-adapted questionnaire and infection diary from the Airway Infection Susceptibility (AWIS) study in a regularly followed, prospective cohort of MS patients. It is a nested project of the prospective observational Swiss MS Cohort (SMSC) and SUMMIT (Serially Unified Multicenter Multiple Sclerosis Investigation) studies.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MS-adapted AWIS questionnaire (MS-AWIS) | Other | The predefined questionnaire-based infection score of the Airway Infection Susceptibility (AWIS) study is predictive for the occurrence of respiratory tract infections (RTI). In addition several MS-specific items (e.g. bladder dysfunction and urinary tract infections) are included into the AWIS questionnaire (MS-AWIS). | ||
| infection diary (MS-AWIS diary) | Other | MS patients prospectively fill out monthly infection diaries for 24 months. Infection diaries will either be sent back (with pre-franked envelopes) or handed back to the InRIMS-study team during regular clinical visits (usually every 6 or 12 months). |
| Measure | Description | Time Frame |
|---|---|---|
| AWIS RTI score | AWIS RTI score is based on the data collected with the MS-adapted AWIS (MS-AWIS) questionnaire; score varies between 0 (no RTI burden) and 50 (maximal RTI burden) | Baseline |
| infection diary score | monthly diary RTI score, averaging ten RTI symptom categories with the coding "0" for "no infection reported", "1" for "reported infection with duration < 2 weeks", and "2" for "reported infection present with duration >2 weeks | 24 months |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of infection scores between patients receiving Disease Modifying Therapies (DMTs) and those who do not receive DMTs | Comparison of infection scores between patients receiving DMTs and those who do not receive DMTs | 24 months |
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Inclusion Criteria:
Exclusion Criteria:
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MS patients participating in the SMSC or SUMMIT study with or without DMT
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| Name | Affiliation | Role |
|---|---|---|
| Bernhard Décard, Dr. med | University Hospital Basel, Department of Neurology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Basel, Department of Neurology | Basel | 4031 | Switzerland |
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| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| D012141 | Respiratory Tract Infections |
| D014552 | Urinary Tract Infections |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
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| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D007239 | Infections |
| D012140 | Respiratory Tract Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |