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Age may pertain to different tumor genotype characteristics which may interfere with treatment efficacy and prognosis. The investigators investigated the distribution and prognostic effect of mutations (mut) and tumor infiltrating lymphocyte (TILs) in young and elderly early breast cancer patients (pts).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| women <35 with early breast cancer |
| ||
| women>65 years old with early breast cancer |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Corellation of Mutations, TILs and Age in Breast Cancer | Genetic |
|
| Measure | Description | Time Frame |
|---|---|---|
| Assessment of the prevalence of gene mutations in women <=35 years old with early breast cancer. | Up to 13 years | |
| Assessment of the prevalence of gene mutations in women >65years old with early breast cancer. | Up to 13 years | |
| Evaluation of Tumor Infiltrating Lymphocytes (TILs) density using descriptive statistics in women <=35 years old with early breast cancer. | Up to 13 years | |
| Evaluation of Tumor Infiltrating Lymphocytes (TILs) density using descriptive statistics in women >65 years old with early breast cancer. | Up to 13 years | |
| Evaluation of the prognostic effect of gene mutations and Tumor Infiltrating Lymphocytes with respect to Overall Survival in women <=35 years old with early breast cancer | Up to 13 years | |
| Evaluation of the prognostic effect of gene mutations and Tumor Infiltrating Lymphocytes with respect to Overall Survival in women >65 years old with early breast cancer. | Up to 13 years |
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Inclusion Criteria:
Exclusion Criteria:
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women with early breast cancer <35 years old or >65 years old
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| Name | Affiliation | Role |
|---|---|---|
| Adamantia Nikolaidi, MD | Oncology Department, MITERA Hospital | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19317994 | Background | Gnerlich JL, Deshpande AD, Jeffe DB, Sweet A, White N, Margenthaler JA. Elevated breast cancer mortality in women younger than age 40 years compared with older women is attributed to poorer survival in early-stage disease. J Am Coll Surg. 2009 Mar;208(3):341-7. doi: 10.1016/j.jamcollsurg.2008.12.001. Epub 2009 Jan 21. | |
| 21779224 |
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| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
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| ID | Term |
|---|---|
| D000375 | Aging |
| ID | Term |
|---|---|
| D048788 | Growth and Development |
| D010829 | Physiological Phenomena |
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formalin-fixed paraffin-embedded
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| D017437 |
| Skin and Connective Tissue Diseases |