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| Name | Class |
|---|---|
| Italian Thyroid Cancer Observatory (ITCO) Foundation | UNKNOWN |
| Catholic University of the Sacred Heart | OTHER |
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The Italian Thyroid Cancer Observatory (ITCO) repository was established to collect data on thyroid cancer management in a prospective and consecutive series of newly-diagnosed patients, enrolled in centers uniformly distributed across the nation.
Little information is available on current practices in the treatment of thyroid cancer: a web-based thyroid cancer database was created to collect real-life data. The participants' network include tertiary referral centers operating at the national level, as well as smaller hospital-based units with local or regional recruitment areas.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients diagnosed with thyroid cancer | Patients with histologically-confirmed diagnoses of papillary, follicular, Hürthle, poorly differentiated, anaplastic, or medullary thyroid cancer |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Standard treatment | Procedure | e.g., surgery, radioiodine therapy, systemic treatments (multikinase inhibitors), surveillance |
|
| Measure | Description | Time Frame |
|---|---|---|
| Disease persistence or recurrence | Composite event of disease persistence or recurrence during clinical follow-up, detected by any of the available imaging tools (neck sonography, computed tomography [CT], magnetic resonance imaging [MRI], or positron emission tomography [PET]) | Up to 10 years from the primary treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Disease persistence after 12-18 months from the primary treatment | Rate of disease persistence after 12-18 months from the primary treatment, detected by any of the available imaging tools (neck sonography, radioiodine whole body scan, computed tomography [CT], magnetic resonance imaging [MRI], or positron emission tomography [PET]) | 12-18 months from the primary treatment |
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Inclusion Criteria:
Exclusion Criteria:
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Patients prospectively and consecutively diagnosed with histologically-confirmed papillary, follicular, Hürthle, poorly differentiated, anaplastic, or medullary thyroid cancer.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Cosimo Durante, MD,PhD | Contact | cosimo.durante@uniroma1.it | ||
| Giorgio Grani, MD,PhD | Contact | giorgio.grani@uniroma1.it |
| Name | Affiliation | Role |
|---|---|---|
| Sebastiano Filetti, MD | Full professor of Internal Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| A.S.S.T. Grande Ospedale Metropolitano Niguarda | Recruiting | Milan | Milano | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29192093 | Result | Lamartina L, Grani G, Arvat E, Nervo A, Zatelli MC, Rossi R, Puxeddu E, Morelli S, Torlontano M, Massa M, Bellantone R, Pontecorvi A, Montesano T, Pagano L, Daniele L, Fugazzola L, Ceresini G, Bruno R, Rossetto R, Tumino S, Centanni M, Meringolo D, Castagna MG, Salvatore D, Nicolucci A, Lucisano G, Filetti S, Durante C. 8th edition of the AJCC/TNM staging system of thyroid cancer: what to expect (ITCO#2). Endocr Relat Cancer. 2018 Mar;25(3):L7-L11. doi: 10.1530/ERC-17-0453. Epub 2017 Nov 30. No abstract available. | |
| 29020892 |
| Label | URL |
|---|---|
| ITCO Foundation homepage | View source |
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| Disease recurrence after 3, 5 and 10 years from the primary treatment | Rate of disease recurrence after 3, 5 and 10 years from the primary treatment, detected by any of the available imaging tools (neck sonography, radioiodine whole body scan, computed tomography [CT], magnetic resonance imaging [MRI], or positron emission tomography [PET]) | 3, 5 and 10 years from the primary treatment |
| Response to primary therapy | Response to primary treatment, evaluated according to the American Thyroid Association guidelines response to treatment: excellent response, biochemical incomplete response, indeterminate response, or structural incomplete response (combination of serum tumor markers and imaging tools, such as neck sonography, radioiodine whole body scan, computed tomography [CT], magnetic resonance imaging [MRI], or positron emission tomography [PET]) | 1, 3, 5 and 10 years after therapy |
| Response to secondary treatments | Response to secondary treatments, evaluated according to the American Thyroid Association guidelines response to treatment: excellent response, biochemical incomplete response, indeterminate response, or structural incomplete response (combination of serum tumor markers and imaging tools, such as neck sonography, radioiodine whole body scan, computed tomography [CT], magnetic resonance imaging [MRI], or positron emission tomography [PET]) | 1, 3, 5 and 10 years after therapy |
| Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico | Recruiting | Milan | Milano | Italy |
|
| IRCCS Ospedale San Raffaele | Recruiting | Milan | Milano | Italy |
|
| Ospedale Regina Apostolorum | Recruiting | Albano Laziale | RM | Italy |
|
| Ospedali Riuniti di Ancona | Recruiting | Ancona | Italy |
|
| Università degli Studi di Bari | Recruiting | Bari | Italy |
|
| Ospedale degli Infermi di Biella | Recruiting | Biella | Italy |
|
| Azienda Unità Sanitaria di Bologna - Ospedale Maggiore | Recruiting | Bologna | Italy |
|
| University of Bologna, S. Orsola Malpighi Hospital | Recruiting | Bologna | Italy |
|
| Università degli Studi di Brescia, Spedali Civili | Recruiting | Brescia | Italy |
|
| Azienda Ospedaliero-Universitaria di Cagliari | Recruiting | Cagliari | Italy |
|
| Azienda Ospedaliero Universitaria "Mater Domini" di Catanzaro | Recruiting | Catanzaro | Italy |
|
| Azienda Ospedaliero Universitaria di Ferrara | Recruiting | Ferrara | Italy |
|
| University of Florence | Recruiting | Florence | Italy |
|
| Ente Ospedaliero Ospedali Galliera | Recruiting | Genova | Italy |
|
| Sapienza University of Rome, Santa Maria Goretti Hospital | Recruiting | Latina | Italy |
|
| Tinchi Pisticci Hospital | Recruiting | Matera | Italy |
|
| Azienda Ospedaliera Universitaria "Gaetano Martino" | Recruiting | Messina | Italy |
|
| Università degli Studi di Milano, Istituto Auxologico | Recruiting | Milan | Italy |
|
| University of Modena and Reggio Emilia | Recruiting | Modena | Italy |
|
| University of Naples Federico II | Recruiting | Naples | Italy |
|
| Azienda Ospedale-Università Padova | Recruiting | Padova | Italy |
|
| Istituto Oncologico del Veneto IRCCS | Not yet recruiting | Padova | Italy |
|
| University of Parma | Recruiting | Parma | Italy |
|
| Istituti Clinici Scientifici Maugeri | Recruiting | Pavia | Italy |
|
| Azienda Ospedaliero Universitaria Pisana | Recruiting | Pisa | Italy |
|
| Bio-Medical Campus University | Recruiting | Roma | Italy |
|
| IRCCS Istituti Fisioterapici Ospitalieri - IFO - Istituto Regina Elena | Recruiting | Roma | Italy |
|
| Sapienza University of Rome, Sant'Andrea Hospital | Recruiting | Roma | Italy |
|
| Sapienza University of Rome | Recruiting | Rome | I-00161 | Italy |
|
| A.O.U. Ruggi d'Aragona | Recruiting | Salerno | Italy |
|
| University of Siena | Recruiting | Siena | Italy |
|
| AOU Città della Salute e della Scienza | Recruiting | Torino | Italy |
|
| University of Turin, Gradenigo Hospital | Recruiting | Torino | Italy |
|
| Azienda Sanitaria Universitaria Friuli Centrale | Recruiting | Udine | Italy |
|
| Result |
| Lamartina L, Durante C, Lucisano G, Grani G, Bellantone R, Lombardi CP, Pontecorvi A, Arvat E, Felicetti F, Zatelli MC, Rossi R, Puxeddu E, Morelli S, Torlontano M, Crocetti U, Montesano T, Giubbini R, Orlandi F, Aimaretti G, Monzani F, Attard M, Francese C, Antonelli A, Limone P, Rossetto R, Fugazzola L, Meringolo D, Bruno R, Tumino S, Ceresini G, Centanni M, Monti S, Salvatore D, Spiazzi G, Mian C, Persani L, Barbaro D, Nicolucci A, Filetti S. Are Evidence-Based Guidelines Reflected in Clinical Practice? An Analysis of Prospectively Collected Data of the Italian Thyroid Cancer Observatory. Thyroid. 2017 Dec;27(12):1490-1497. doi: 10.1089/thy.2017.0299. Epub 2017 Nov 10. |
| 32475305 | Result | Grani G, Zatelli MC, Alfo M, Montesano T, Torlontano M, Morelli S, Deandrea M, Antonelli A, Francese C, Ceresini G, Orlandi F, Maniglia CA, Bruno R, Monti S, Santaguida MG, Repaci A, Tallini G, Fugazzola L, Monzani F, Giubbini R, Rossetto R, Mian C, Crescenzi A, Tumino D, Pagano L, Pezzullo L, Lombardi CP, Arvat E, Petrone L, Castagna MG, Spiazzi G, Salvatore D, Meringolo D, Solaroli E, Monari F, Magri F, Triggiani V, Castello R, Piazza C, Rossi R, Ferraro Petrillo U, Filetti S, Durante C. Real-World Performance of the American Thyroid Association Risk Estimates in Predicting 1-Year Differentiated Thyroid Cancer Outcomes: A Prospective Multicenter Study of 2000 Patients. Thyroid. 2021 Feb;31(2):264-271. doi: 10.1089/thy.2020.0272. Epub 2020 Jul 1. |
| 34541894 | Result | Forleo R, Grani G, Alfo M, Zilioli V, Giubbini R, Zatelli MC, Gagliardi I, Piovesan A, Ragni A, Morelli S, Puxeddu E, Pagano L, Deandrea M, Ceresini G, Torlontano M, Puligheddu B, Antonelli A, Centanni M, Fugazzola L, Spiazzi G, Monti S, Rossetto R, Monzani F, Tallini G, Crescenzi A, Sparano C, Bruno R, Repaci A, Tumino D, Pezzullo L, Lombardi CP, Ferraro Petrillo U, Filetti S, Durante C, Castagna MG. Minimal Extrathyroidal Extension in Predicting 1-Year Outcomes: A Longitudinal Multicenter Study of Low-to-Intermediate-Risk Papillary Thyroid Carcinoma (ITCO#4). Thyroid. 2021 Dec;31(12):1814-1821. doi: 10.1089/thy.2021.0248. Epub 2021 Oct 20. |
| 36795619 | Result | Grani G, Gentili M, Siciliano F, Albano D, Zilioli V, Morelli S, Puxeddu E, Zatelli MC, Gagliardi I, Piovesan A, Nervo A, Crocetti U, Massa M, Sama MT, Mele C, Deandrea M, Fugazzola L, Puligheddu B, Antonelli A, Rossetto R, D'Amore A, Ceresini G, Castello R, Solaroli E, Centanni M, Monti S, Magri F, Bruno R, Sparano C, Pezzullo L, Crescenzi A, Mian C, Tumino D, Repaci A, Castagna MG, Triggiani V, Porcelli T, Meringolo D, Locati L, Spiazzi G, Di Dalmazi G, Anagnostopoulos A, Leonardi S, Filetti S, Durante C. A Data-Driven Approach to Refine Predictions of Differentiated Thyroid Cancer Outcomes: A Prospective Multicenter Study. J Clin Endocrinol Metab. 2023 Jul 14;108(8):1921-1928. doi: 10.1210/clinem/dgad075. |
| ID | Term |
|---|---|
| D013964 | Thyroid Neoplasms |
| D000077273 | Thyroid Cancer, Papillary |
| D018263 | Adenocarcinoma, Follicular |
| D065646 | Thyroid Carcinoma, Anaplastic |
| D018276 | Carcinoma, Medullary |
| ID | Term |
|---|---|
| D004701 | Endocrine Gland Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D006258 | Head and Neck Neoplasms |
| D004700 | Endocrine System Diseases |
| D013959 | Thyroid Diseases |
| D000231 | Adenocarcinoma, Papillary |
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D018278 | Carcinoma, Neuroendocrine |
| D018358 | Neuroendocrine Tumors |
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
| D018299 | Neoplasms, Ductal, Lobular, and Medullary |
| D009380 | Neoplasms, Nerve Tissue |
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