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In this study, we aim to analyse the effect of phosphate supplementation on donors undergoing partial hepatectomy for LDLT. In Group A, we are going to supplement phosphate in donors postoperatively from day 1 to day 5. We will analyse the trend of serum phosphate levels in donors postoperatively, its correlation with occurrence of postoperative complications and status of liver regeneration by CT volumetry on Day 7. Group B will constitute the controls for the study and hence attempt to find out the effect of phosphate supplementation in all donors postoperatively. We will analyse the data and elucidate the value of phosphate supplementation in reducing the occurrence of complications and effect on liver regeneration in donors in LDLT.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention Arm - potassium phosphate injection | Experimental |
| |
| Control Arm | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Potassium Phosphate Injection | Drug | One ml of the preparation contains 3 mmol of phosphorous which when equated with RDA 10ml ie 30 mmol of preparation will be supplemented. The preparation is given slowly, intravenously over 4 hours diluted in 500 ml normal saline |
| Measure | Description | Time Frame |
|---|---|---|
| Post operative complications | Outcome of phosphate supplementation in reducing the occurrence of postoperative complications assessed by Clavien Dindo grading | 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Trend of serum phosphorous levels | Serum phosphorous levels will be done daily and its trend will be compared in both the groups | 1 week |
| Trends in post-operative liver function tests | Liver function tests will be done in both groups and its correlation with serum phosphate levels will be correlated |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Viniyendra Pamecha, Professor | Professor and Head, Department of HPB surgery and Liver transplantation, ILBS, New Delhi. | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of Liver and Biliary Sciences | New Delhi | 110070 | India |
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| 1 week |
| Duration of hospital, ICU stay | ICU stay and total hospital stay in the group will be assessed | Till patient is discharged on an average of 10 days |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| C013216 | potassium phosphate |
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