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The investigators will collect blood samples of different courses of VKH patients for investigating immune profile, observe major immune cells number ,functional and membrane molecular changes in the course of treatment, to investigate pathogenesis of VKH. Meanwhile, the investigators will collect clinical data of VKH patients to observe choroid and retina change in different courses.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| VKH patients | acute VKH patients |
| |
| control | health people age/sex match to the VKH patients |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Steroids | Drug | IV and oral steroids |
|
| Measure | Description | Time Frame |
|---|---|---|
| T/B /NK(natural killer )/monocyte...etc, cell numbers of blood samples in VKH patients | use flow cytometry to count T/B /NK/monocyte...etc, cell numbers | one year |
| T/B /NK/monocyte...etc cell subtype proportion in blood samples in VKH patients | use flow cytometry to measure T/B /NK/monocyte...etc cell subtype proportion | one year |
| T/B /NK/monocyte...etc cell functional change in VKH patients | use ELISA(enzyme linked immunosorbent assay) to measure inflammatory cytokines level in peripheral blood | one year |
| Measure | Description | Time Frame |
|---|---|---|
| choroid and retinal thickness change in different course of VKH patients | Use OCT（optical coherence tomography） to measure choroid and retina thickness changes in macular zone of different course VKH patients | one year |
| Use OCTA(optical coherence tomography angiography) to measure macular and optic disc vascular index |
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Inclusion Criteria:
Exclusion Criteria:
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acute primary VKH patients
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zhaohui Li, Ph.D/MD | Contact | +86-186-2790-1441 | lizhaohui@whu.edu.cn | |
| Yafei Huang, Ph.d | Contact | +86-136-2862-7928 | huangyf@tjh.tjmu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Qing Zhang, MD | Central-southern university, Aier ophthalmology colleage | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Wuhan Aier eye hospital | Recruiting | Wuhan | Hubei | 430064 | China |
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| ID | Term |
|---|---|
| D014607 | Uveomeningoencephalitic Syndrome |
| ID | Term |
|---|---|
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D014605 | Uveitis |
| D014603 | Uveal Diseases |
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| ID | Term |
|---|---|
| D013256 | Steroids |
| ID | Term |
|---|---|
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
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blood sample of VKH patients
Use OCTA to measure macular and optic disc vascular index in different course VKH patients |
| one year |
| Use Maia perimeter to measure macular integrality | Use Maia perimeter to measure macular integrality including light threshold and central fixation. | one year |
| measure the Injury degree of choroid and retinal vessels | Use FFA(fluorescein fundus angiography)/ICG(Indocyanine Green Angiography) to measure the Injury degree of choroid and retinal vessels | one year |
| D005128 | Eye Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |