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| ID | Type | Description | Link |
|---|---|---|---|
| 2019-A00736-51 | Other Identifier | ANSM |
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Acute physiological consequences of ultra-marathon running are still unknown, particularly in women. Some studies have suggested that the proportion of fatigue attributable to peripheral and central mechanisms varies between males and females; however, results are contradictory.
The results from the investigators of the present experiment in two studies conducted in 2009 and 2012 showed that:
According to the literature, there seems to be a plateau in fatigue after 12-15 hours of running.
Thus, the main purpose of the present project is to investigate whether sex differences in neuromuscular fatigue in plantar flexors depend on the distance (> 100 km vs < 60 km).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| female subjects involved in races over 100 km (F>100) | Experimental | Female subjects involved in races over 100 km (F>100) will be included. They will have neuromuscular tests in isometric mode, Transcranial Magnetic Stimulation (TMS), neuromuscular fatigue assessment test, treadmill, blood sample and urinary sample. |
|
| female subjects involved in races less than 60 km (F<60) | Experimental | Female subjects involved in races less than 60 km (F<60) will be included. They will have neuromuscular tests in isometric mode, Transcranial Magnetic Stimulation (TMS), neuromuscular fatigue assessment test, treadmill, blood sample and urinary sample. |
|
| male subjects involved in races over 100 km (H>100) | Experimental | Male subjects involved in races over 100 km (H>100) will be included. They will have neuromuscular tests in isometric mode, Transcranial Magnetic Stimulation (TMS), neuromuscular fatigue assessment test, treadmill, blood sample and urinary sample. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Neuromuscular tests in isometric mode | Other | Protocol for neuromuscular tests in isometric mode will be assessed by the composite of these measures :
|
| Measure | Description | Time Frame |
|---|---|---|
| Variation (%) of the amplitudes of the electric shock | Measured by the electrically evoked force after contraction in isometric mode of the plantar flexors | 5 or 6 day before the race and 1 hour after |
| Measure | Description | Time Frame |
|---|---|---|
| Voluntary maximum forces plantar flexors | Analysis :
Measured by voluntary maximum forces plantar flexors test (seat type Cybex) in percentage (%). | 5 or 6 day before the race and 1 hour after |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Léonard FEASSON, MD PhD | Centre Hospitalier Universitaire de Saint Etienne | Principal Investigator |
| Guillaume MILLET, PhD | University of Saint-Etienne | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Saint-Etienne | Saint-Etienne | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33198320 | Result | Robert M, Stauffer E, Nader E, Skinner S, Boisson C, Cibiel A, Feasson L, Renoux C, Robach P, Joly P, Millet GY, Connes P. Impact of Trail Running Races on Blood Viscosity and Its Determinants: Effects of Distance. Int J Mol Sci. 2020 Nov 12;21(22):8531. doi: 10.3390/ijms21228531. | |
| 34170574 | Result | Temesi J, Besson T, Parent A, Singh B, Martin V, Brownstein CG, Espeit L, Royer N, Rimaud D, Lapole T, Feasson L, Millet GY. Effect of race distance on performance fatigability in male trail and ultra-trail runners. Scand J Med Sci Sports. 2021 Sep;31(9):1809-1821. doi: 10.1111/sms.14004. Epub 2021 Jul 12. |
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| male subjects involved in races less than 60 km (H<60) | Experimental | Male subjects involved in races less than 60 km (H<60) will be included. They will have neuromuscular tests in isometric mode, Transcranial Magnetic Stimulation (TMS), neuromuscular fatigue assessment test, treadmill, blood sample and urinary sample. |
|
|
| Transcranial Magnetic Stimulation (TMS) | Device | Measure of supraspinal activation level and cortical excitation by Transcranial Magnetic Stimulation (TMS). |
|
| Neuromuscular fatigue assessment test | Other | Neuromuscular fatigue assessment test in dynamic mode will be assessed by the Force/Velocity Profile (FVP) measure: 2 sprints of 8 seconds on a cycle ergometer. |
|
| treadmill | Other | 2 sessions of treadmill will be realized: 8 and 10 km.h-1 for level running and 7 km.h-1 with 10% slope for graded running. |
|
| Blood sample | Biological | Blood sample will be realized to measure hemorrheologic and hematologic parameters. |
|
| Urinary sample | Biological | Urinary sample will be realized to measure hemorrheologic and hematologic parameters. |
|
| Voluntary maximum forces knee extensors | Analysis :
Voluntary maximum forces knee extensors measures by seat type Cybex in percentage (%). | 5 or 6 day before the race and 1 hour after |
| Electrically evoked forces | Analysis :
Electrically evoked forces measures by neurostimulator in percentage (%). | 5 or 6 day before the race and 1 hour after |
| ElectroMyoGraphic activity (EMG) | Analysis :
ElectroMyoGraphic activity (EMG) measures by electromyography. The EMG signal will be recorded with pairs of electrodes fixed with an adhesive tape bilaterally over the muscular belly. | 5 or 6 day before the race and 1 hour after |
| Three-Modality Evoked Potentials (TMEPs) | Analysis :
Three-Modality Evoked Potentials (TMEPs) measures by magnetic stimulator in percentage (%). | 5 or 6 day before the race and 1 hour after |
| Transcranial Magnetic Stimulation (TMS) | Analysis :
Measured supraspinal activation level and cortical excitation by Transcranial Magnetic Stimulation (TMS) in percentage (%). | 5 or 6 day before the race and 1 hour after |
| Force/Velocity Profile (FVP) | Analysis:
Measured Force/Velocity Profile (FVP) test: 2 sprints of 8 seconds on a cycle ergometer. | 5 or 6 day before the race and 1 hour after |
| Blood viscosity | Measured by blood sample. | 5 or 6 day before the race and 1 hour after |
| Number of red blood cell | Measured by blood sample. | 5 or 6 day before the race and 1 hour after |
| Number of platelets | Measured by blood sample. | 5 or 6 day before the race and 1 hour after |
| Number of white blood cells | Measured by blood sample. | 5 or 6 day before the race and 1 hour after |
| Rate of hemoglobin (%) | Measured by blood sample. | 5 or 6 day before the race and 1 hour after |
| creatinine (mg/L) | Measured by blood sample. | 5 or 6 day before the race and 1 hour after |
| C reactive protein (CRP) (mg/L) | Measured by blood sample. | 5 or 6 day before the race and 1 hour after |
| urea (g/L) | Measured by blood sample. | 5 or 6 day before the race and 1 hour after |
| uric acid (mg/L) | Measured by blood sample. | 5 or 6 day before the race and 1 hour after |
| lactate (mg/L) | Measured by blood sample. | 5 or 6 day before the race and 1 hour after |
| Proteinuria-density urinary (mg/24h) | Measured by urinary sample. | 5 or 6 day before the race and 1 hour after |
| Kinematic variable | Measured by treadmill result. | 5 or 6 day before the race and 1 hour after |
| 35730335 | Result | Foure A, Besson T, Stauffer E, Skinner SC, Bouvier J, Feasson L, Connes P, Hautier CA, Millet GY. Sex-related differences and effects of short and long trail running races on resting muscle-tendon mechanical properties. Scand J Med Sci Sports. 2022 Oct;32(10):1477-1492. doi: 10.1111/sms.14203. Epub 2022 Jul 6. |
| 35213820 | Result | Pastor FS, Besson T, Varesco G, Parent A, Fanget M, Koral J, Foschia C, Rupp T, Rimaud D, Feasson L, Millet GY. Performance Determinants in Trail-Running Races of Different Distances. Int J Sports Physiol Perform. 2022 Jun 1;17(6):844-851. doi: 10.1123/ijspp.2021-0362. Epub 2022 Feb 25. |
| 33666727 | Result | Sabater Pastor F, Varesco G, Besson T, Koral J, Feasson L, Millet GY. Degradation of energy cost with fatigue induced by trail running: effect of distance. Eur J Appl Physiol. 2021 Jun;121(6):1665-1675. doi: 10.1007/s00421-021-04624-5. Epub 2021 Mar 5. |
| 35730761 | Derived | Trama R, Blache Y, Hintzy F, Rossi J, Millet GY, Hautier C. Does neuromuscular fatigue generated by trail running modify foot-ground impact and soft tissue vibrations? Eur J Sport Sci. 2023 Jul;23(7):1155-1163. doi: 10.1080/17461391.2022.2093649. Epub 2022 Jul 10. |
| 34107510 | Derived | Besson T, Parent A, Brownstein CG, Espeit L, Lapole T, Martin V, Royer N, Rimaud D, Sabater Pastor F, Singh B, Varesco G, Rossi J, Temesi J, Millet GY. Sex Differences in Neuromuscular Fatigue and Changes in Cost of Running after Mountain Trail Races of Various Distances. Med Sci Sports Exerc. 2021 Nov 1;53(11):2374-2387. doi: 10.1249/MSS.0000000000002719. |
| ID | Term |
|---|---|
| D050781 | Transcranial Magnetic Stimulation |
| D005080 | Exercise Test |
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D055909 | Magnetic Field Therapy |
| D013812 | Therapeutics |
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D012129 | Respiratory Function Tests |
| D003948 | Diagnostic Techniques, Respiratory System |
| D016552 | Ergometry |
| D008919 | Investigative Techniques |
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
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