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This study aims to investigate whether acceptable image quality is achievable using low contrast media dose and low keV imaging in chronic kidney disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Low dose | Experimental | Low CT contrast media dose |
|
| Standard dose | Active Comparator | Standard CT contrast media dose |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| low dose CT contrast media | Other | CT contrast media (Ioversol 320mgI/kg) is administrated at a dose of 300mgI/kg in low dose group |
|
| Measure | Description | Time Frame |
|---|---|---|
| Overall image quality | qualitative scoring for image quality on five-point scale (1: worst, 5: excellent, representative value is average score) | 6 months after complete enrollment |
| Measure | Description | Time Frame |
|---|---|---|
| Contrast media (CM) dose | administered CM dose in each group | 3 months after complete enrollment |
| Incidence of Contrast media-induced nephrotoxicity | serum Cr level increase by 25% or more of the baseline, or 0.5mg/dl in 3 days after contrast media administration without other cause |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jeong Min Lee, MD | Seoul National University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37858212 | Derived | Yoon JH, Park JY, Lee SM, Lee ES, Kim JH, Lee JM. Renal protection CT protocol using low-dose and low-concentration iodine contrast medium in at-risk patients of HCC and with chronic kidney disease: a randomized controlled non-inferiority trial. Cancer Imaging. 2023 Oct 19;23(1):100. doi: 10.1186/s40644-023-00616-0. |
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| Standard dose CT contrast media | Other | CT contrast media (Ioversol 350mgI/kg) is administrated at a dose of 525mgI/kg in standard dose group. |
|
| 3 days after contrast media administration |
| Image contrast | qualitative scoring for image contrast on five-point scale (1: worst, 5: excellent, representative value is average score) | 12 months after complete enrollment |
| Lesion conspicuity | qualitative scoring for focal lesion depiction on five-point scale | 12 months after complete enrollment |
| lesion (HCC) detection | detection rate of focal liver lesion/HCC on CT | 12 months after complete enrollment |