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The objectives of this study are to assess molecular testing, treatment patterns and associated clinical outcomes in Chinese patients with treatment-naïve stage III non-small cell lung cancer (NSCLC) in real world setting. This study is a prospective, non-interventional study. It is descriptive in nature and does not attempt to test any specific a priori hypotheses.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cohort 1 | Cohort 1, including patients without surgical resection, will be defined as unresectable stage III NSCLC | ||
| Cohort 2 | Cohort 2,including patients with surgical resection, will be defined as resectable stage III NSCLC |
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| Measure | Description | Time Frame |
|---|---|---|
| To observe treatment patterns of unresectable, stage III NSCLC | Treatment received before disease progress including chemotherapy, targeted therapy, immunotherapy, anti-angiogenesis therapy and radiotherapy | Date of enrollment in the study until end of follow-up or death if this occurs before, assessed approximately up to 36 months |
| Measure | Description | Time Frame |
|---|---|---|
| To observe the clinical outcome of unresectable, stage III NSCLC | Overall survival measured from the date of treatment initiation in the study to the date of death due to any cause; Progression-free Survival (PFS) measured from the date of treatment initiation in the study, until physician-reported progression or death due to any cause, whichever occurs first. | Date of enrollment in the study until end of follow-up or death if this occurs before, assessed approximately up to 36 months |
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Inclusion Criteria:
Exclusion Criteria:
Enrolment in studies that prohibit any participation in this observational study.
Prior surgery, radiotherapy or systemic therapy for NSCLC, including chemotherapy, targeted therapy, anti-angiogenesis, etc.
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Stage III NSCLC patients who received no prior systemic therapy for NSCLC before study enrolment
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Research Site | Beijing | China | 100020 | China | ||
| Research Site |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42070217 | Derived | Xing L, Yu J, Meng X, Zhao R, Yang W, Guo Y, Li J, Fan M, Xiao C, Ren Y, Dong L, Lv D, Zhao L, Lin Y, Zhang X, Chen L, Wang Y, Zhang Y, Zang A, Cheng G, Liu A, Liang N, Lou B, Wang J, Fu X, Shi A, Xu N, Liu J, Xiang ZL. Real-World Treatment Patterns and Clinical Outcomes Among Chinese Patients with Stage III NSCLC: The MOOREA Study. Target Oncol. 2026 May;21(3):385-398. doi: 10.1007/s11523-026-01217-0. Epub 2026 May 3. |
| Label | URL |
|---|---|
| CSR Synopsis\_redacted | View source |
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| ID | Term |
|---|---|
| D002289 | Carcinoma, Non-Small-Cell Lung |
| ID | Term |
|---|---|
| D002283 | Carcinoma, Bronchogenic |
| D001984 | Bronchial Neoplasms |
| D008175 | Lung Neoplasms |
| D012142 | Respiratory Tract Neoplasms |
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| To observe molecular testing patterns of stage III NSCLC | Molecular testing patterns including: Molecular testing rate defined as the number of patients who received molecular testing divided by total patient's number; Molecular testing details including sample type, test type; Molecular testing results. | Date of enrollment in the study until end of follow-up or death if this occurs before, assessed approximately up to 36 months |
| To estimate parameters associated with radiation pneumonitis | Assessment of radiation pneumonitis observed with radiotherapy among patients with unresectable, stage III NSCLC | Date of enrollment in the study until end of follow-up or death if this occurs before, assessed approximately up to 36 months |
| To observe adjuvant treatment patterns of resectable, stage III NSCLC | Adjuvant treatment received post surgery including chemotherapy, targeted therapy and radiotherapy. | Date of enrollment in the study until end of follow-up or death if this occurs before, assessed approximately up to 36 months |
| Beijing |
| China |
| 100044 |
| China |
| Research Site | Beijing | China | China |
| Research Site | Datong | China | 030000 | China |
| Research Site | Datong | China | China |
| Research Site | Fenyang | China | China |
| Research Site | Guangzhou | China | China |
| Research Site | Hefei | China | 330006 | China |
| Research Site | Jinan | China | 2501117 | China |
| Research Site | Nanning | China | 530021 | China |
| Research Site | Qingdao | China | China |
| Research Site | Shantou | China | China |
| Research Site | Taizhou | China | China |
| Research Site | Tianjin | China | China |
| Research Site | Yinchuan | China | 750004 | China |
| Research Site | Changchun | 130021 | China |
| Research Site | Chengdu | 610041 | China |
| Research Site | Chengdu | 610042 | China |
| Research Site | Hong Kong | China |
| Research Site | Shanghai | 200030 | China |
| Research Site | Shanghai | 200040 | China |
| Research Site | Shanghai | China |
| Research Site | Shijiazhuang | 050011 | China |
| Research Site | Shijiazhuang | 063000 | China |
| Research Site | Shijiazhuang | 430079 | China |
| D013899 |
| Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |