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The RA patients receiving leflunomide for more than one month, and not receiving other DMARDs (except hydroxychloroquine), will be enrolled to assess their disease activity. Blood samples will be collected for genetic studies and pharmacokinetic assay of the blood levels of the drug and its active metabolite.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| leflunomide responsive vs non-responsive |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Leflunomide 20Mg Tab | Drug | blood samples of rheumatoid patients will be collected for SNPs detection and drug assay |
|
| Measure | Description | Time Frame |
|---|---|---|
| Detection of single nucleotide polymorphisms associated with response to the drug | SNPs associated with the response or adverse drug reactions will be detected and correlated with the ratio of leflunomide to its active metabolite | one -two years |
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Inclusion Criteria:
Exclusion Criteria:
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Rheumatoid arthritis patients from both sexes with different disease activity status receiving solely leflunomide with or without hydroxychloroquine
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Assiut University Hospital | Asyut | Egypt |
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| ID | Term |
|---|---|
| D001172 | Arthritis, Rheumatoid |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
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| ID | Term |
|---|---|
| D000077339 | Leflunomide |
| ID | Term |
|---|---|
| D007555 | Isoxazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| D003240 |
| Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |