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No participants enrolled
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To investigate the effect of radiotherapy on peripheral blood immune cell composition and function in pediatric malignant brain tumor patients.
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| Measure | Description | Time Frame |
|---|---|---|
| The changes of peripheral blood immune cells | The flow cytometric analysis of lymphocyte subtypes populations would be performed | 6 weeks (prior and post the radiation therapy ) |
| Measure | Description | Time Frame |
|---|---|---|
| Activation status of T cells | Activation status of peripheral IFN-γ-producing effector CD8+ T cells by Elispot. | 6 weeks (prior and post the radiation therapy ) |
| The changs of inflammatory cytokines and chemokines |
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Inclusion Criteria:
Exclusion Criteria:
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The brain tumors patients between the ages of 3 year and 18 years who will be received radiation therapy evaluated and determined by their physician
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Shijitan Hospital Cancer Center | Beijing | China |
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| ID | Term |
|---|---|
| D001932 | Brain Neoplasms |
| ID | Term |
|---|---|
| D016543 | Central Nervous System Neoplasms |
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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Human inflammatory cytokines and chemokines will be analyzed by ELISA during radiation therapy. The cytokines and chemokines are IL-2, IL-10, IFN-γ, TNF-α
| 6 weeks (prior and post the radiation therapy ) |
| D001927 |
| Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |