Immunomodulation Analysis of Radiation Therapy in Pediatric Malignant Brain Tumors

Immunomodulation Analysis on Peripheral Blood Mononuclear Cells of Radiation Therapy in Pediatric Malignant Brain Tumors

To investigate the effect of radiotherapy on peripheral blood immune cell composition and function in pediatric malignant brain tumor patients.

Inclusion Criteria:

• Age from 3 to 18
• To be diagnosed with malignant brain tumors
• To eligible for radiation therapy
• Karnofsky performance status ≥ 70
• No prior radiation exposure
• Informed consent signed for blood sample collection and used for research purpose

Exclusion Criteria:

• Patients had received radiotherapy previously.
• Patients who had no histological diagnosis
• Patients who do not wish to participate
• Patients with infections