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In this study, we investigated the effect of low-frequency repetitive trans cranial magnetic stimulation, one of the noninvasive brain stimuli, on the functional changes of the bilateral motor cortical activity in normal subjects using functional near infrared spectroscopy (fNIRS).
In normal subjects,
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Navigated low frequency rTMS | Experimental | Application of 1Hz low frequency repetitive transcranial magnetic stimulation to the primary motor area of the dominant hemisphere using a navigation system. Using the BrainSight instrument, a navigation system, the TMS coil position can be fixed on the point precise target area based on the subject's MRI image. |
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| only low frequency rTMS(not using Navigation System) | Experimental | Application of low frequency repetitive transcranial magnetic stimulation to the primary motor area of the dominant hemisphere not using a navigation system. TMS coil is fixed on the target area based on MEP hotspot. |
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| Navigated Sham rTMS | Sham Comparator | Application of repetitive transcranial magnetic stimulation with sham mode(no stimulation) to the primary motor area of the dominant hemisphere using a navigation system. Using the BrainSight instrument, a navigation system, the TMS coil position can be fixed on the point precise target area based on the subject's MRI image. Sham stimulation is stimulated by the same frequency, intensity and time as the actual stimulus in such a way that the 8-shaped coil is placed at a 90 degree angle to the scalp in the same manner as rTMS and sounds are heard but the magnetic stimulus is not transmitted to the cerebrum |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| low frequency rTMS + Navigation System | Device | 1Hz low-frequency rTMS stimulation over primary motor area using navigation system |
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| Measure | Description | Time Frame |
|---|---|---|
| Changes of Cortical activation | Cortical activation is measured by functional Near-Infrared-Spectroscopy (fNIRS) (NIRScout, NIRx, Germany) before and after stimulation | Baseline and after intervention[Immediately after 20 minutes of intervention] |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in motor evoked potentia | measure the motor threshold and amplitude of motor evoked potential in first dorsal interosseous muscle. | Baseline and after intervention[Immediately after 20 minutes of intervention] |
| changes in nine hole peg test |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yun-Hee Kimm, MD, PhD | Samsung Medical Center | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Samsung Medical Center | Seoul | South Korea |
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| only low frequency rTMS | Device | 1Hz low-frequency rTMS stimulation over primary motor area |
|
| Sham low frequency rTMS + Navigation System | Device | 1Hz low-frequency sham rTMS stimulation over primary motor area using navigation system |
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Nine-Hole Peg Test is used to measure finger dexterity in patients with various neurological diagnoses.
| Baseline and after intervention[Immediately after 20 minutes of intervention] |
| Sequential motor task | It is a training exercise in which five digits are repeatedly pressed with five fingers using individual movements, and it is trained to press the button accurately and quickly. | Baseline and after intervention[Immediately after 20 minutes of intervention] |