Influence of Preprandial Metformin Administration on Carbohydrate Absorption

Influence of Preprandial Metformin Administration on Carbohydrate Absorption: Pilot Randomized Controlled Study

Type 2 diabetes is spreading worldwide as well as obesity. Metformin is the most prescribed antidiabetic medication. One suggested mechanism of action is by decreasing carbohydrate absorption.

It is usually recommended to take metformin during the meal to decrease gastrointestinal side effects. However, if metformin decreases carbohydrate absorption, this might not be the most efficient intake.

To study the influence of preprandial metformin administration on carbohydrate absorption, it will repeat 3 oral glucose tolerance test on obese dysglycemic patients, without metformin or with metformin administer 30 or 60 minutes before. We will also evaluate how it impacts gastrointestinal tolerance.

Inclusion Criteria:

• Obesity (BMI ≥30 kg/m2)
• Dysglycemia (HbA1c≥ 6,0 %)
• No anti diabetic medication

Exclusion Criteria:

• No obesity (BMI < 30 kg/m2)
• No dysglycemia (HbA1c <6,0%)
• Treatment that might interfere with carbohydrate absorption (anti diabetic medication, antibiotics, probiotics, steroids)
• Anemia (Hb <12 g/dL)
• Organ failure
• Inflammatory Bowel Disease