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Chronic Obstructive Pulmonary Disease (COPD) is a frequent disease affecting a growing number of adults in the world which is responsible for a large public health burden through heavy morbidity and mortality.
Emphysema is one of a wide spectrum of pulmonary complications linked to COPD, defined as the abnormal permanent enlargement of the airspaces distal to the terminal bronchioles accompanied by destruction of the alveolar wall. Disease progression is correlated to worsening and enlargement of emphysema lesions, sometimes conflating in sizeable bullae, deleterious to normal mechanical pulmonary function. Bullous emphysema (BE) is sometimes eligible to invasive curative treatment through surgery or interventional bronchoscopy.
Diagnosis of BE relies on computerized tomodensitometry (CT), the gold-standard for evaluating pulmonary parenchyma. However, CT is not always available, and bullous emphysema can present as pneumothorax on chest radiography.
The practice of lung ultrasound is currently growing in respiratory medicine and emergency departments owing to an increasing amount of evidence showcasing its reliability as a diagnostic tool, most notably for pneumothorax and other pleural diseases. Despite BE having been reported to present similarly to pneumothorax in ultrasound, its characteristics have not yet been precisely described.
The primary aim of this study is to describe BE using lung ultrasound. Participants with known BE on CT will undergo a simple ultrasound examination. The secondary aim is to compare the characteristics of BE to those of pneumothorax using lung ultrasound. To achieve this, a second group of participants with currently treated pneumothorax will also undergo lung ultrasound.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bullous emphysema | Participants with known bullous emphysema will undergo lung ultrasound according to standard of care clinical practice during a regular follow-up consultation or scheduled hospitalization. |
| |
| Pneumothorax | Participants hospitalized in pulmonary medicine units for the treatment of a pneumothorax will undergo lung ultrasound according to standard of care clinical practice. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lung ultrasound | Diagnostic Test | Non-invasive external ultrasonography of the chest wall |
|
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of various ultrasound signs in the bullous emphysema group, according to a predetermined sonographic evaluation form, following a standardized segmentation of the chest | The following sonographic signs will be investigated :
For qualitative signs, the investigators will present proportions Quantitative signs will be reported using means, medians and standard-deviations | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of various ultrasound signs in the pneumothorax group, according to a predetermined sonographic evaluation form, following a standardized segmentation of the chest | The following sonographic signs will be investigated :
For qualitative signs, the investigators will present proportions Quantitative signs will be reported using means, medians and standard-deviations |
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Inclusion Criteria:
Bullous emphysema group
Pneumothorax group
Exclusion Criteria:
Bullous emphysema group
All patients
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Participants will be recruited from multiple Pulmonary Departments in France, in the setting of University Hospitals. All participants fulfilling inclusion criteria will be included.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pulmonary Medicine, Thoracic Oncology and Respiratory Intensive Care Department, Rouen University Hospital | Rouen | 76000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40059443 | Derived | El Husseini K, Flament T, Laroumagne S, Basille D, Le Brun M, Noel-Savina E, Richard P, Mangiapan G, Artaud-Macari E. Mapping Bullous Emphysema With Lung Ultrasound: A Prospective Multicentre Study. Respirology. 2025 Jul;30(7):633-643. doi: 10.1111/resp.70021. Epub 2025 Mar 9. |
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| ID | Term |
|---|---|
| D011656 | Pulmonary Emphysema |
| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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| ID | Term |
|---|---|
| D003952 | Diagnostic Imaging |
| D012129 | Respiratory Function Tests |
| D012149 | Restraint, Physical |
| ID | Term |
|---|---|
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D003948 | Diagnostic Techniques, Respiratory System |
| D032763 | Behavior Control |
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| Chest radiography | Diagnostic Test | Chest radiography to search for visible pleural edge, synonym with persistent pneumothorax |
|
| Pulmonary function tests | Diagnostic Test | Pulmonary function evaluation as part of routine care for emphysematous patients |
|
| Clinical examination | Other | Standard clinical examination performed by investigating physician |
|
| 2 years |
| Statistical comparison of ultrasound characteristics of bullous emphysema and pneumothorax |
| 2 years |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D013812 | Therapeutics |
| D007103 | Immobilization |
| D008919 | Investigative Techniques |