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The aim of the present study is to investigate epigenetics based modifications and biomarkers in the saliva and blood in diabetic patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Type 2 diabetic patients |
| ||
| Prediabetic patients |
| ||
| Women with gestational diabetes |
| ||
| Healthy control subjects |
| ||
| Pregnant women without gestational diabetes |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood sampling | Diagnostic Test | After a fasting period over night blood samples will be taken. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Specifying the microRNAs in saliva in diabetic patients | Characterization of microRNAs in saliva of prediabetic and type 2 diabetic patients, as well as in women with gestational diabetes and healthy control subjects. | 1 hour |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation of the percentage of liver fat with miRNA´s in diabetic patients. | Correlation of miRNA´s in the saliva with the amount of intrahepatic liver fat. | 1 hours |
| Correlation of the percentage of heart fat with miRNA´s in diabetic patients |
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Inclusion Criteria:
Exclusion Criteria:
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In the present study prediabetic patients, type 2 diabetic patients, women with gestational diabetes and healthy control subjects will be included.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Alexandra Kautzky-Willer, Univ.Prof.Dr. | Contact | +434040021260 | alexandra.kautzky-willer@meduniwien.ac.at | |
| Michael Leutner, Dr.med.univ., MSc | Contact | michael.leutner@meduniwien.ac.at |
| Name | Affiliation | Role |
|---|---|---|
| Alexandra Kautzky-Willer, Univ.Prof.Dr. | Department of Internal Medicine III, Clinical Division of Endocrinology and Metabolism, Unit of Gender Medicine, Medical University of Vienna | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical University of Vienna | Recruiting | Vienna | 1090 | Austria |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32820618 | Derived | Klepochova R, Leutner M, Bastian M, Krebs M, Weber M, Trattnig S, Kautzky-Willer A, Krssak M. Muscle-Specific Relation of Acetylcarnitine and Intramyocellular Lipids to Chronic Hyperglycemia: A Pilot 3-T 1H MRS Study. Obesity (Silver Spring). 2020 Aug;28(8):1405-1411. doi: 10.1002/oby.22846. |
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| ID | Term |
|---|---|
| D011236 | Prediabetic State |
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| Saliva and blood samples | Diagnostic Test | After a fasting period over night blood and saliva samples will be taken for the investigation of epigenetics based modifications. |
|
| Magnet Resonance Spectroscopy | Diagnostic Test | The amount of ectopic lipids in the liver, heart and the skeletal muscle will be measured using 1H-magnetic resonance spectroscopy. |
|
Correlation of miRNA´s in the saliva with the amount of ectopic lipids in the heart.
| 1 hour |
| Correlation of the percentage of the content of fat in the skeletal muscle with miRNA´s in diabetic patients. | Correlation of miRNA´s in the saliva with the amount of ectopic lipids in the skeletal muscle. | 1 hour |
| D004700 | Endocrine System Diseases |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |