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| Name | Class |
|---|---|
| NOVA Medical School | OTHER |
| Centro Hospitalar De São João, E.P.E. | OTHER |
| Hospital de Braga | OTHER |
| Centro de Investigação em Tecnologias e Serviços de Saúde |
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Data from 2007 regarding iodine status among Portuguese pregnant women indicate this is an iodine deficient population group, with only 16.8% presenting adequate urinary iodine values. This may have serious implications for normal cognitive development of the offspring and a concerning socioeconomic impact. In 2013, concerns by the Portuguese Directorate-General of Health lead to the implementation of a public health policy (nº 011/2013) recommending iodine supplementation during pregnancy. IoMum emerges from this context to monitor and update iodine status in Portuguese pregnant women and to evaluate the effectiveness of the above policy by assessing clinical compliance to iodine supplementation and the impact of iodine supplementation in this vulnerable group. IoMum will update data on iodine nutrition in Portuguese pregnant women, promoting political actions towards the elimination of iodine deficiency and thus to the reduction of nutritional, social and economic inequalities.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| IOMUM | Pregnant women |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Urinary Iodine Concentration Measurement | Diagnostic Test | UIC |
|
| Measure | Description | Time Frame |
|---|---|---|
| 1st trimester urinary iodine concentration | Median urinary iodine concentration at 1st trimester of gestation | Between gestational weeks 10 and 13 plus 6 days (one timepoint collection - Timepoint 1) |
| Rate of compliance to iodine supplementation guideline | Rate of compliance to iodine supplementation guideline at 1st trimester of gestation | Between gestational weeks 10 and 13 plus 6 days (one timepoint collection - Timepoint 1) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in median iodine-to-creatinine ratio | Change in median iodine-to-creatinine ratio between 1st and 3rd trimesters of gestation | Up to 31 weeks |
| Proportion of pregnant women with insufficient, adequate or excessive iodine intake |
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Inclusion Criteria:
Exclusion Criteria:
Only pregnant women included
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Portuguese pregnant women
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| Name | Affiliation | Role |
|---|---|---|
| Elisa Keating, PhD | Center for Health Technology and Services Research | Principal Investigator |
| Conceição Calhau, PhD | Center for Health Technology and Services Research | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine of the University of Porto | Porto | 4200-319 | Portugal |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35635644 | Derived | Matta Coelho C, Guimaraes J, Bracchi I, Xavier Moreira N, Pinheiro C, Ferreira P, Pestana D, Barreiros Mota I, Cortez A, Prucha C, Martins C, Pinto E, Almeida A, Delerue-Matos C, Dias CC, Moreira-Rosario A, Ribeiro de Azevedo LF, Cruz Fernandes V, Ramalho C, Calhau C, Brantsaeter AL, Costa Leite J, Keating E. Noncompliance to iodine supplementation recommendation is a risk factor for iodine insufficiency in Portuguese pregnant women: results from the IoMum cohort. J Endocrinol Invest. 2022 Oct;45(10):1865-1874. doi: 10.1007/s40618-022-01813-7. Epub 2022 May 30. |
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| OTHER |
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Classification of pregnant women by urinary iodine concentration levels according to WHO criteria (insufficient, adequate or excessive iodine intake) at 1st trimester of gestation.
| Between gestational weeks 10 and 13 plus 6 days (one timepoint collection - Timepoint 1) |
| Maternal median thyroglobulin | Maternal median thyroglobulin at 3rd trimester of gestation | Between gestational weeks 35 and 41 (one timepoint collection - Timepoint 2) |
| 1st trimester mean sodium excretion | Mean sodium excretion at 1st trimester of gestation | Between gestational weeks 10 and 13 plus 6 days (one timepoint collection - Timepoint 1) |
| 3rd trimester mean sodium excretion | Mean sodium excretion at 3rd trimester of gestation | Between gestational weeks 35 and 41 (one timepoint collection - Timepoint 2) |