A Registered Cohort Study on Spastic Paraplegia

A Registered Cohort Study on Spastic Paraplegia

The aim of this study is to determine the clinical spectrum and natural progression of Hereditary Spastic Paraplegias(HSP) and related disorders in a prospective multicenter natural history study, to assess the clinical, genetic and epigenetic features of patients with Spastic Paraplegias to optimize clinicalmanagement..

Inclusion Criteria:

• Patients with the clinical diagnosis of spastic paraplegia
• Clinical diagnosis of patients with spastic paraplegia
• Unrelated healthy controls

Exclusion Criteria:

• Decline to participate.
• There are serious interferences with individual participation and adherence to the research protocol, including but not limited to neurological, psychological, and/or medical conditions.