Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Northumbria Healthcare NHS Foundation Trust | OTHER |
Not provided
Not provided
Not provided
Not provided
Not provided
Worldwide, colorectal cancer is the 3rd most common cancer; risk increases with age and is modified by lifestyle factors notably diet, physical activity and obesity. The BORICC Follow-Up (BFU) Study is a 12+ year follow-up of participants recruited to the Biomarkers of Risk of Colon Cancer (BORICC) Study. This longitudinal study will investigate associations between ageing and lifestyle factors and a panel of molecular biomarkers linked with colorectal cancer risk.
The BORICC Follow-Up (BFU) Study builds on the findings from the BORICC Study where the investigators observed associations between age and nutritional factors, including selenium and folate, and biomarkers of colorectal health.
The BFU Study will investigate the relationships between ageing (12+ years) and such biomarkers longitudinally. It is anticipated that the project will produce novel data on (i) changes in biomarkers of colorectal cancer risk with age and (ii) the effects of obesity and lifestyle factors on biomarkers of colorectal cancer risk. These biomarkers include differentially expressed proteins, DNA methylation markers and inflammation markers.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy | Participants recruited to the healthy arm of the BORICC Study (BORICC1) at baseline. | ||
| Polyp | Participants recruited to the polyp arm of the BORICC Study (BORICC2) at baseline, with a prior history of polyps. |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Faecal calprotectin concentrations (marker of local inflammation) | 12 years (on average) | |
| Serum high-sensitivity C-Reactive Protein concentrations (marker of systemic inflammation) | 12 years (on average) |
| Measure | Description | Time Frame |
|---|---|---|
| Gut microbiota (analysed in stool samples) | Abundance and diversity of the gut microbiota assessed in stool samples | 12 years (on average) |
| Faecal short-chain fatty acid concentrations | Concentrations and proportions of short-chain fatty acids e.g. acetate, propionate and butyrate |
| Measure | Description | Time Frame |
|---|---|---|
| Timed-up and go test time | 12 years (on average) | |
| Hand grip strength using dynamometer | 12 years (on average) | |
| Heel bone density using Achilles heel ultrasound device |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Participants who took part in the BORICC Study at baseline (2005/06) will be invited to participate in the BFU Study. This will include both participants recruited to the BORICC1 arm (healthy participants) and those recruited to the BORICC2 arm, with a prior history of polyps.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| John Mathers | Newcastle University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| North Tyneside General Hospital | North Shields | Tyne & Wear | NE29 8NH | United Kingdom |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| D009765 | Obesity |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
Not provided
Not provided
Not provided
Not provided
Not provided
| 12 years (on average) |
| DNA methylation in rectal mucosal biopsies(% methylation) | Target gene and global methylation (LINE-1) in rectal mucosal biopsies | 12 years (on average) |
| Target gene expression in rectal mucosal biopsies | Expression of genes related to inflammation and the WNT signalling pathway in rectal mucosal biopsies | 12 years (on average) |
| microRNA expression in rectal mucosal biopsies | Expression of microRNAs in rectal mucosal biopsies | 12 years (on average) |
| Colonic crypt cell proliferative state | Total number and distribution of proliferating cells in rectal mucosal crypts | 12 years (on average) |
| Colonic crypt cell dimensions | Height (length) and width rectal mucosal crypts | 12 years (on average) |
| Markers of mitochondrial function and structure in rectal mucosal biopsies | Markers of mitochondrial function and structure in rectal mucosal biopsies such as oxidative phosphorylation proteins, namely complex I and IV | 12 years (on average) |
| Parathyroid hormone in plasma | 12 years (on average) |
| 25-hydroxy vitamin D concentrations in serum | 12 years (on average) |
| Vitamin B12 concentrations in serum | 12 years (on average) |
| Folate concentrations in serum | 12 years (on average) |
| Triglycerides in plasma | 12 years (on average) |
| HDL cholesterol in plasma | 12 years (on average) |
| LDL cholesterol in plasma | 12 years (on average) |
| Total cholesterol in plasma | 12 years (on average) |
| Glucose in plasma | 12 years (on average) |
| HbA1c in whole blood | 12 years (on average) |
| 12 years (on average) |
| Body weight in kg | 12 years (on average) |
| BMI in kg/m2 (calculated from height and weight) | 12 years (on average) |
| Height in cm | 12 years (on average) |
| Body fat percentage | Measured using Tanita Bioimpedance scales | 12 years (on average) |
| Habitual dietary intake assessed using Food Frequency Questionnaire | 12 years (on average) |
| Physical activity levels assessed using Lifestyle Questionnaire | 12 years (on average) |
| Physical activity levels assessed using accelerometer | 12 years (on average) |
| Sedentary behaviour assessed using Lifestyle Questionnaire | 12 years (on average) |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |