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To study the diagnostic performance of infrared spectroscopy on fresh synovial fluids in early septic arthritis diagnosis in patients with acute joint effusion
Diagnosis of a joint effusion is frequently a medical emergency, especially when septic arthritis is suspected. Septic arthritis diagnosis relies on microscopic and bacteriological analysis of synovial fluid obtained by arthrocentesis. Direct microscopic examination can be made within 2 to 12 hours but it is negative in about 50 % of the cases. It is necessary to wait 72 hours to obtain the result of the culture and reasonably rule out the diagnosis of septic arthritis. A method of establishing an immediate etiological diagnosis could improve the care of patients with joint effusion that is a therapeutic emergency and justify a hospitalization and a parenteral antibiotic therapy.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Infrared spectroscopy | Device | Infrared spectroscopy |
| Measure | Description | Time Frame |
|---|---|---|
| Diagnosis of the cause of joint effusion | The final diagnosis of the cause of joint effusion is made by the clinician based on the clinical and laboratory data : septic arthritis or other causes of arthritis | Up to 7 days (time to perform Spectroscopy and collect laboratory results) |
| Measure | Description | Time Frame |
|---|---|---|
| Number of days of hospitalization | The clinician will be asked to state how a positive or a negative result of the diagnostic test under study would have affected his decision to hospitalize the patient | Up to 2 months (time to collect data on hospitalization duration and antibiotic therapy duration) |
| Total dose of antibiotics |
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Inclusion Criteria:
Exclusion Criteria:
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Patients benefiting from joint fluid puncture for diagnostic purposes in the rheumatology hospitals participating in the study
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Angers | Angers | 49933 | France | |||
| CHRU Brest |
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| ID | Term |
|---|---|
| D006833 | Hydrarthrosis |
| ID | Term |
|---|---|
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
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The clinician will be asked to state how a positive or a negative result of the diagnostic test under study would have affected his decision to start antibiotic therapy |
| Up to 2 months (time to collect data on hospitalization duration and antibiotic therapy duration) |
| Brest |
| 29200 |
| France |
| CHU Clermont-Ferrand | Clermont-Ferrand | 63003 | France |
| CHU Nantes | Nantes | 44000 | France |
| CHU de Rennes | Rennes | 35033 | France |
| CHRU Tours | Tours | 37044 | France |