Pharmaceutical Intervention and Adherence to bDMARDs in Spondyloarthritis.

Impact of a Pharmacist's Intervention on Knowledge and Adherence to Biologic Disease-modifying Drugs in Patients With Spondyloarthritis: a Randomised Controlled Trial.

There is a lack of knowledge among patients concerning their treatment with bDMARDs, which could lead to low adherence.

The objective of this study is to assess the impact of a pharmacist's intervention on the adherence to bDMARDs in patients with Spondyloarthritis.

This is an interventional, controlled, open-label and monocentric study. 80 patients are planned to be included.

After written informed consent will be obtained, the patients will be randomized in two arms:

• Intervention arm: intervention of a pharmacist who will explain bDMARDs management.
• Control arm, without intervention.

Two primary end-points are defined:

1. the changes from baseline to M6 in the patients' knowledge score about subcutaneous bDMARD management
2. the changes from baseline to M6 in Medication Possession Ratio (MPR)

As secondary end-points, the changes in disease activity and patients' satisfaction regarding the pharmacists' intervention are evaluated.

Inclusion Criteria:

• Outpatients from Rheumatology Department at Cochin Hospital
• Diagnosis of Spondyloarthritis
• Under treatment with subcutaneous bDMARDs for at least 6 months
• Disease activity stable for at least 6 months
• No treatment modification 3 months before or after inclusion in the study
• Informed consent signed and dated
• Older than 18 years
• Patients who speak french

Exclusion Criteria:

• Patients who have had a change in the treatment of SpA during the 3 months prior or after the inclusion
• History of psychological problems
• Patients who need other persons to manage their treatment.